{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:26:20Z","timestamp":1793341580282,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Cholecystitis is a major complication after self\u2010expandable metallic stent (<jats:styled-content style=\"fixed-case\">SEMS<\/jats:styled-content>) placement for malignant biliary obstruction. Ischemia is one of the risk factors for cholecystitis, but little is known about the influence of tumor invasion to the feeding artery of the gallbladder on the onset of cholecystitis after <jats:styled-content style=\"fixed-case\">SEMS<\/jats:styled-content> placement. The aim of the present study was to identify risk factors for cholecystitis after <jats:styled-content style=\"fixed-case\">SEMS<\/jats:styled-content> placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Incidence and nine predictive factors of cholecystitis were retrospectively evaluated in 107 patients who underwent <jats:styled-content style=\"fixed-case\">SEMS<\/jats:styled-content> placement for unresectable distal malignant biliary obstruction at Kyoto University Hospital and Otsu Red Cross Hospital between January 2012 and June 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cholecystitis occurred in 13 of 107 patients (12.1%) after <jats:styled-content style=\"fixed-case\">SEMS<\/jats:styled-content> placement during the median follow\u2010up period of 262 days. Univariate analyses showed that tumor invasion to the feeding artery of the gallbladder and tumor involvement to the orifice of the cystic duct were significant predictors of cholecystitis (<jats:italic>P<\/jats:italic> = 0.001 and <jats:italic>P<\/jats:italic> &lt; 0.001). Multivariate analysis confirmed that these two factors were significant and independent risks for cholecystitis with odds ratios of 22.13 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 3.57\u2013137.18; <jats:italic>P<\/jats:italic> = 0.001) and 25.26 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 4.12\u2013154.98; <jats:italic>P<\/jats:italic> &lt; 0.001), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed for the first time that tumor invasion to the feeding artery of the gallbladder as well as tumor involvement to the orifice of the cystic duct are independent risk factors for cholecystitis after <jats:styled-content style=\"fixed-case\">SEMS<\/jats:styled-content> placement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12991","type":"journal-article","created":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T03:55:26Z","timestamp":1511841326000},"page":"380-387","source":"Crossref","is-referenced-by-count":22,"title":["Tumor invasion to the arteries feeding the gallbladder as a novel risk factor for cholecystitis after metallic stent placement in distal malignant biliary obstruction"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0623-3871","authenticated-orcid":false,"given":"Yuko","family":"Sogabe","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine Kyoto Japan"},{"name":"Department of Gastroenterology and Hepatology Otsu Red Cross Hospital Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzo","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Honjo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Otsu Red Cross Hospital Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Otsu Red Cross Hospital Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Muramoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Otsu Red Cross Hospital Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Otsu Red Cross Hospital Shiga 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