{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:08:12Z","timestamp":1777306092419,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>A risk\u2010stratified approach for selecting patients likely to harbor common bile duct (<jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>) stones to proceed directly to endoscopic or surgical stone clearance, rather than undergo less invasive testing, has been proposed. We assessed the performance of three clinical algorithms used to predict <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> stones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients undergoing first\u2010time endoscopic retrograde cholangiopancreatography (<jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content>) in 2011\u20132012 as a result of suspected <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> stones were enrolled prospectively in a clinical database. Data such as imaging test findings and liver function tests (LFTs) were collected 48 h prior to and on the day of <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content>. Patients were stratified into different risk groups for harboring <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> stones according to three clinical algorithms using imaging and laboratory data. Findings on <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content> were used as gold standard. Performance characteristics of each algorithm were separately calculated for each time point of <jats:styled-content style=\"fixed-case\">LFT<\/jats:styled-content> assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 186 patients were analyzed, 75% of whom presented <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> stones on <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content>. Proportion of patients categorized as high\u2010risk for harboring <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> stones varied among the three algorithms (67% <jats:italic>vs<\/jats:italic> 73% <jats:italic>vs<\/jats:italic> 56%). Also, the algorithms showed only moderate, albeit comparable, accuracy for predicting the presence of <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> stones (0.65, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.62\u20130.68 <jats:italic>vs<\/jats:italic> 0.68, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.63\u20130.67 <jats:italic>vs<\/jats:italic> 0.59, 95%<jats:styled-content style=\"fixed-case\"> CI<\/jats:styled-content> 0.57\u20130.61). Similar results were obtained when performance characteristics were recalculated using <jats:styled-content style=\"fixed-case\">LFT<\/jats:styled-content> from 48 h prior to <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content> (data not shown).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Three diagnostic algorithms commonly used for predicting <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> stones have comparable but only moderate accuracy. Further research is warranted to improve risk stratification of patients with suspected <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content> stones.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12994","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T07:18:39Z","timestamp":1512112719000},"page":"477-484","source":"Crossref","is-referenced-by-count":12,"title":["Current clinical algorithms for predicting common bile duct stones have only moderate accuracy"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4474-4098","authenticated-orcid":false,"given":"Mohamed","family":"Ebrahim","sequence":"first","affiliation":[{"name":"Digestive Disease Center Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars T.","family":"Sorensen","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars N.","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelos","family":"Kalaitzakis","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"},{"name":"Endoscopy Unit Digestive Disease Center Copenhagen University Hospital\/Herlev University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.03.005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.07.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i21.3267"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01511.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.09.041"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199407000-00006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1993.01420170085012"},{"key":"e_1_2_6_10_1","first-page":"762","article-title":"Predicting the presence of choledocholithiasis in patients with symptomatic cholelithiasis","volume":"91","author":"Onken JE","year":"1996","journal-title":"Am. 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