{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T03:49:42Z","timestamp":1773114582603,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T00:00:00Z","timestamp":1516579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Center for the Prevention and Diagnosis of Celiac Disease in the Gastroenterology and Endoscopy unit of the Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico in Milan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The role of capsule endoscopy (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>) in established celiac disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) remains unclear. Our objective was to analyze the usefulness of <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> in the suspicion of complicated <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective multicenter study. One hundred and eighty\u2010nine celiac patients (mean age: 46.6\u00a0\u00b1\u00a016.6, 30.2% males) who underwent <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> for alarm symptoms (<jats:italic>n<\/jats:italic>\u00a0=\u00a086, 45.5%) or non\u2010responsive <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0103, 54.5%) were included. Diagnostic yield (<jats:styled-content style=\"fixed-case\">DY<\/jats:styled-content>), therapeutic impact and safety were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Capsule endoscopy was completed in 95.2% of patients (small bowel transit time: 270.5\u00a0\u00b1\u00a0100.2\u00a0min). Global <jats:styled-content style=\"fixed-case\">DY<\/jats:styled-content> was 67.2%, detecting atrophic mucosa (<jats:italic>n<\/jats:italic>\u00a0=\u00a092, 48.7%), ulcerative jejunoileitis (<jats:italic>n<\/jats:italic>\u00a0=\u00a021, 11.1%), intestinal lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a07, 3.7%) and other enteropathies (<jats:italic>n<\/jats:italic>\u00a0=\u00a07, 3.7%, six Crohn's disease cases and one neuroendocrine tumor).<\/jats:p><jats:p>The <jats:styled-content style=\"fixed-case\">DY<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> was significantly higher in patients presenting with non\u2010responsive disease compared to patients with alarm symptoms (73.8% <jats:italic>vs<\/jats:italic> 59.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.035). The new findings of the <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> modified management in 59.3% of the cases. There were no major complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Capsule endoscopy may be a moderately helpful and safe diagnostic tool in the suspicion of complicated <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>, modifying the clinical course of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.13002","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T17:32:35Z","timestamp":1513618355000},"page":"461-466","source":"Crossref","is-referenced-by-count":29,"title":["Role of capsule endoscopy in alarm features and non\u2010responsive celiac disease: A European multicenter study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8254-7453","authenticated-orcid":false,"given":"Enrique","family":"Perez\u2010Cuadrado\u2010Robles","sequence":"first","affiliation":[{"name":"Small Bowel Unit Morales Meseguer Hospital Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisol","family":"Lujan\u2010Sanchis","sequence":"additional","affiliation":[{"name":"Digestive Diseases Unit General University Hospital of Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Elli","sequence":"additional","affiliation":[{"name":"Center for Prevention and Diagnosis of Celiac Disease Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose\u2010Francisco","family":"Juanmartinena\u2010Fernandez","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit Navarra Hospital Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Garc\u0131a\u2010Lledo","sequence":"additional","affiliation":[{"name":"Digestive Diseases Unit General University Hospital Gregorio Mara\u00f1on Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u0131a","family":"Ruano\u2010D\u0131az","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toledo Hospital Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Egea\u2010Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University Hospital Virgen de la Arrixaca Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria\u2010Alejandra","family":"Jimenez\u2010Garc\u0131a","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit University Hospital Virgen Macarena Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Arguelles\u2010Arias","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit University Hospital Virgen Macarena Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mileidis San","family":"Juan\u2010Acosta","sequence":"additional","affiliation":[{"name":"Digestive Diseases Unit University Hospital Nuestra Se\u00f1ora de Candelaria Tenerife Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-2890","authenticated-orcid":false,"given":"Cristina","family":"Carretero\u2010Ribon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Navarra Clinic Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelia","family":"Alonso\u2010Lazaro","sequence":"additional","affiliation":[{"name":"Endoscopy Digestive Unit Digestive Diseases Unit University Hospital La Fe Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Rosa","sequence":"additional","affiliation":[{"name":"Digestive Diseases Unit Senhora da Oliveira Hospital Guimaraes Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Sanchez\u2010Ceballos","sequence":"additional","affiliation":[{"name":"Digestive Diseases Unit San Carlos Hospital Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Lopez\u2010Higueras","sequence":"additional","affiliation":[{"name":"Digestive Diseases Unit General University Hospital of Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Fernandez\u2010Urien\u2010Sainz","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit Navarra Hospital Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Branchi","sequence":"additional","affiliation":[{"name":"Center for Prevention and Diagnosis of Celiac Disease Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Valle\u2010Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toledo Hospital Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Borque\u2010Barrera","sequence":"additional","affiliation":[{"name":"Digestive Diseases Unit University Hospital Nuestra Se\u00f1ora de Candelaria Tenerife Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Gonzalez\u2010Vazquez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Navarra Clinic Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Pons\u2010Beltran","sequence":"additional","affiliation":[{"name":"Endoscopy Digestive Unit Digestive Diseases Unit University Hospital La Fe Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sof\u0131a","family":"Xavier","sequence":"additional","affiliation":[{"name":"Digestive Diseases Unit Senhora da Oliveira Hospital Guimaraes Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Begona","family":"Gonzalez\u2010Suarez","sequence":"additional","affiliation":[{"name":"Endoscopy Digestive Unit Hospital Clinic of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan\u2010Manuel","family":"Herrer\u0131as\u2010Gutierrez","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit University Hospital Virgen Macarena Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Perez\u2010Cuadrado\u2010Mart\u0131nez","sequence":"additional","affiliation":[{"name":"Digestive Diseases Unit General University Hospital of Valencia Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Sempere\u2010Garc\u0131a\u2010Arguelles","sequence":"additional","affiliation":[{"name":"Small Bowel Unit Morales Meseguer Hospital Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Enteroscopy and Capsule Endoscopy Spanish Society Group of the Spanish Society of Digestive Endoscopy (SEED)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2015.07.025"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32834fa914"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0486-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.10.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v7.i1.13"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i29.10024"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.01.044"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870310"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.12.032"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.02.015"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1391855"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.04.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.07.021"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31826bea12"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301346"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.79"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.4146"},{"key":"e_1_2_8_19_1","first-page":"171","article-title":"Histology of gluten related disorders","volume":"8","author":"Marsh NM","year":"2015","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369510"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101808"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2012.07.013"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.199"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(05)01566-X"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.05.049"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.09.031"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01122.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-861322"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-921045"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2011.00561.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01238.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-015-0370-7"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.04.004"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.11.019"},{"key":"e_1_2_8_35_1","first-page":"143","article-title":"From capsule endoscopy to balloon\u2010assisted deep enteroscopy: exploring small\u2010bowel endoscopic imaging","volume":"11","author":"Cooley DM","year":"2015","journal-title":"Gastroenterol. Hepatol. (NY)"}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.13002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.13002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/den.13002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.13002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T06:34:54Z","timestamp":1694068494000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.13002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,22]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/den.13002"],"URL":"https:\/\/doi.org\/10.1111\/den.13002","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,22]]}}}