{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:20:46Z","timestamp":1791991246977,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2013\u20100418"],"award-info":[{"award-number":["2013\u20100418"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Little is known about the standard care of small (&lt;2 cm in diameter) pancreatic neuroendocrine tumors (<jats:styled-content style=\"fixed-case\">PNET<\/jats:styled-content>). The aim of the present study was to determine the clinical outcomes of small <jats:styled-content style=\"fixed-case\">PNET<\/jats:styled-content> after endoscopic ultrasound (<jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>)\u2010guided ethanol\u2010lipiodol ablation (<jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ELA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective cohort study, consecutive patients who underwent <jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ELA<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">PNET<\/jats:styled-content> were enrolled and were followed for \u22653 years. Treatment efficacy was the primary outcome measure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 33 patients who had 40 pathologically confirmed <jats:styled-content style=\"fixed-case\">PNET<\/jats:styled-content> (&lt;2 cm in diameter) were enrolled for final analysis. A total of 63 <jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ELA<\/jats:styled-content> sessions were successfully carried out (mean, 1.9 sessions per patient, 1.6 sessions per tumor), which included 40 initial sessions and 23 repeated sessions owing to incomplete ablation. Median actual volume of ethanol\u2010lipiodol mixture injected per session was 1.1 mL (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 0.8\u20131.9 mL). Complete ablation was achieved in 24 of 40 tumors (60%) with one (18 tumors, 45%) or two (24 tumors, 60%) sessions of <jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ELA<\/jats:styled-content>. Lipiodol retention within tumor had better treatment outcomes (<jats:italic>P<\/jats:italic> = 0.004). Rate of procedure\u2010related adverse events was 3.2%. No malignancy or lymph node metastasis was discovered during a median follow up of 42 months (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 39\u201346 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found that <jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ELA<\/jats:styled-content> was a safe and effective alternative option in the management of <jats:styled-content style=\"fixed-case\">PNET<\/jats:styled-content> &lt;2.0 cm in diameter; 60% of patients achieved complete ablation. Lipiodol retention within tumor may be a useful early predictor of treatment effectiveness. Trial registered at ClinicalTrials.gov (<jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content> 01902238).<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.13058","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T16:03:42Z","timestamp":1521993822000},"page":"652-658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Outcomes after endoscopic ultrasound\u2010guided ethanol\u2010lipiodol ablation of small pancreatic neuroendocrine tumors"],"prefix":"10.1111","volume":"30","author":[{"given":"Jun\u2010Ho","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Dankook University College of Medicine Dankook University Hospital Cheonan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine University of Ulsan College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung\u2010Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine University of Ulsan College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Sang","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Ulsan College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Mo","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Ulsan College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Jun","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology 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