{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:05:01Z","timestamp":1767164701974,"version":"build-2238731810"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T00:00:00Z","timestamp":1531958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Public Trust Fund For Clinical Cancer Research"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2018,11]]},"abstract":"\n Background and Aim<\/jats:title>\n \n Pancreatic ductal adenocarcinoma (\n PDAC<\/jats:styled-content>\n ) is difficult to detect in its early stages with the poorest prognosis of all cancers. To improve the prognosis, a precise diagnosis is needed when we suspect\n PDAC<\/jats:styled-content>\n . Although endoscopic ultrasound\u2010guided fine\u2010needle aspiration biopsy (\n EUS<\/jats:styled-content>\n \u2010\n FNA<\/jats:styled-content>\n ) is a widely accepted modality for the diagnosis of\n PDAC<\/jats:styled-content>\n , its sensitivity is 85\u201389%, and approximately 10% of\n PDAC<\/jats:styled-content>\n cases cannot be diagnosed. The main causes that interrupt the diagnosis of\n PDAC<\/jats:styled-content>\n by using\n EUS<\/jats:styled-content>\n \u2010\n FNA<\/jats:styled-content>\n are tumor size, presence of a vessel or the main pancreatic duct along the puncture route, and difficulty in withdrawing anticoagulant. Pancreatic juice cytology (\n PJC<\/jats:styled-content>\n ), the sensitivity of which is 33.3\u201365.8%, is a method for the diagnosis of\n PDAC<\/jats:styled-content>\n cases in which carrying out of\n EUS<\/jats:styled-content>\n \u2010\n FNA<\/jats:styled-content>\n is difficult. To diagnose\n PDAC<\/jats:styled-content>\n appropriately, we need to improve the diagnostic ability of\n PJC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We examined\n PJC<\/jats:styled-content>\n using synthetic secretin for 138 cases of pancreatic tumor and pancreatic non\u2010cancerous diseases.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Sensitivity of\n PJC<\/jats:styled-content>\n improved from 50.9% to 74.0% as a result of synthetic secretin loading, and 13\n PDAC<\/jats:styled-content>\n cases that had not been able to be diagnosed with\n EUS<\/jats:styled-content>\n \u2010\n FNA<\/jats:styled-content>\n could be diagnosed pathologically by\n PJC<\/jats:styled-content>\n . Although there were 12 patients with mild pancreatitis (8.7%) as a complication, all were relieved with conservative treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Adding synthetic secretin to\n PJC<\/jats:styled-content>\n is useful for cases in which it is difficult to carry out\n EUS<\/jats:styled-content>\n \u2010\n FNA<\/jats:styled-content>\n for\n PDAC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/den.13203","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T02:23:51Z","timestamp":1528251831000},"page":"771-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy and safety of pancreatic juice cytology by using synthetic secretin in the diagnosis of pancreatic ductal adenocarcinoma"],"prefix":"10.1111","volume":"30","author":[{"given":"Yohei","family":"Takeda","sequence":"first","affiliation":[{"name":"Faculty of Medicine Medicine and Clinical Science Tottori University Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Medicine and Clinical Science Tottori University Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Kurumi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Medicine and Clinical Science Tottori University Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Koda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Medicine and Clinical Science Tottori University Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Medicine and Clinical Science Tottori University Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Onoyama","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Medicine and Clinical Science Tottori University Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Kawata","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Medicine and Clinical Science Tottori University Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Pathology Tottori University Hospital Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-7865","authenticated-orcid":false,"given":"Hajime","family":"Isomoto","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Medicine and Clinical Science Tottori University Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12071"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.08.049"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1393076"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2003.79"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481235"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1215323"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196805000-00013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)32748-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.03900.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2071-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31825d60fc"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v8.i9.656"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921201)70:11<2610::AID-CNCR2820701107>3.0.CO;2-Y"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000606"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12332"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/528304"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(91)70740-2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0684-y"},{"key":"e_1_2_7_21_1","unstructured":"ChiRhoClin Inc. 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