{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:56:34Z","timestamp":1789419394598,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2019,3]]},"abstract":"\n Background and Aim<\/jats:title>\n \n Endoscopic papillectomy (\n EP<\/jats:styled-content>\n ) has been attempted not only for benign lesions but also for early ampullary carcinoma (\n AC<\/jats:styled-content>\n ). However, there is still no sufficient evidence or consensus regarding the effectiveness of\n EP<\/jats:styled-content>\n for early\n AC<\/jats:styled-content>\n . Herein, we evaluated the expanding indication of\n EP<\/jats:styled-content>\n for early\n AC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Between May 1999 and December 2016, 177 patients were diagnosed with ampullary tumor before undergoing\n EP<\/jats:styled-content>\n , and their clinical and histopathological data were analyzed retrospectively.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were 27 Tis\u2010T1a\n AC<\/jats:styled-content>\n patients and four T1b\n AC<\/jats:styled-content>\n patients who underwent\n EP<\/jats:styled-content>\n . Mean tumor size was 14.1 mm for Tis\u2010T1a\n AC<\/jats:styled-content>\n and 17.0 mm for T1b\n AC<\/jats:styled-content>\n . For the histological grade, 50% (2\/4) of T1b\n AC<\/jats:styled-content>\n were moderately differentiated, whereas 96.3% (26\/27) of Tis\u2010T1a\n AC<\/jats:styled-content>\n were well differentiated and papillary. For lymphovascular invasion, one (25%) occurred in T1b\n AC<\/jats:styled-content>\n but none occurred in Tis\u2010T1a\n AC<\/jats:styled-content>\n . There was no\n AC<\/jats:styled-content>\n recurrence from the date of\n EP<\/jats:styled-content>\n until a maximum of 5 years (Tis\u2010T1a: mean period 48.5 months [5\u201360]; T1b: mean period 26.5 months [3\u201360]).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Endoscopic papillectomy is useful and reliable for the curative treatment of T1a\n AC<\/jats:styled-content>\n . Large\u2010scale prospective studies with long\u2010term follow up are needed.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/den.13265","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T15:21:10Z","timestamp":1535642470000},"page":"188-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Expanding the indication of endoscopic papillectomy for T1a ampullary carcinoma"],"prefix":"10.1111","volume":"31","author":[{"given":"Kenjiro","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9433-8437","authenticated-orcid":false,"given":"Takao","family":"Itoi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University Tokyo 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