{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:58:59Z","timestamp":1776095939506,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Current evidence supporting the utility of single\u2010operator peroral cholangioscope (<jats:styled-content style=\"fixed-case\">SOPOC<\/jats:styled-content>) in the management of difficult bile duct stones is limited. We conducted the present systematic review and meta\u2010analysis to evaluate the efficacy and safety of <jats:styled-content style=\"fixed-case\">SOPOC<\/jats:styled-content> in treating difficult bile duct stones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched studies up to April 2018, using <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content>, the Cochrane Library, and Google Scholar. Quality assessment of the studies was completed with the Newcastle\u2010Ottawa Scale. Main outcomes were complete stone clearance rate, single\u2010session stone clearance rate, number of endoscopic sessions needed for stone clearance, and adverse\u00a0events. We calculated the pooled estimates with random\u2010effects models. Potential publication bias was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four studies involving 2786 patients met the inclusion criteria. Pooled proportion of patients with complete stone clearance was 94.3% (95% confidence interval [95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>]: 90.2\u201397.5%). Single\u2010session stone clearance was achieved in 71.1% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 62.1\u201379.5%) of the pooled patients. Pooled number of sessions needed for stone clearance was 1.26 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.17\u20131.34%). Pooled adverse event rate was 6.1% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 3.8\u20138.7%). Potential publication bias was detected but had no significant influence on the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Single\u2010operator peroral cholangioscope is an effective and safe treatment for difficult bile duct stones when conventional methods have failed. More randomized controlled trials are warranted to confirm the results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.13307","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T16:09:30Z","timestamp":1542989370000},"page":"256-269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Single\u2010operator peroral cholangioscope in treating difficult biliary stones: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"31","author":[{"given":"Zheng","family":"Jin","sequence":"first","affiliation":[{"name":"Hangzhou Geriatric Hospital Hangzhou First People\u2019s Hospital Group Hangzhou China"},{"name":"Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Wei","sequence":"additional","affiliation":[{"name":"Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6064-0526","authenticated-orcid":false,"given":"Xiaowei","family":"Tang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Southwest Medical University Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sisi","family":"Shen","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hangbin","family":"Jin","sequence":"additional","affiliation":[{"name":"Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2016.1212658"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2010.00953.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2007.01.025"},{"key":"e_1_2_7_5_1","first-page":"146","article-title":"A randomized assessment of a semi\u2010disposable, fiberoptic single\u2010operator cholangioscope with a fully\u2010disposable, digital single\u2010operator cholangioscope in a biliary tract bench model","volume":"3","author":"Shah RJ","year":"2015","journal-title":"United European Gastroenterol. 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