{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:38:58Z","timestamp":1792226338959,"version":"4.4.0"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p>Photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>), a treatment of choice for cancer, induces a photochemical reaction, thereby eradicating tumor cells. This is achieved through the administration of a photosensitizer drug, which is activated with a laser after localization to the tumor mass, and is an approved curative endoscopic ablative treatment for superficial esophageal squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">ESCC<\/jats:styled-content>) in Japan. <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> has been approved for dysplastic Barrett's esophagus and as a palliative treatment for patients with symptomatic obstructive esophageal cancer in <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>. However, its adverse events and complicated procedure and the development of alternative endoscopic procedures such as endoscopic submucosal dissection, radiofrequency ablation and cryotherapy, have largely limited the practice of <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> in esophageal cancer worldwide. Recently, owing to the invention of second\u2010generation <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> using talaporfin sodium and diode laser, <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> can be performed with less phototoxicity and therefore has regained popularity in the treatment of <jats:styled-content style=\"fixed-case\">ESCC<\/jats:styled-content>. As a salvage treatment for patients with local failure after chemoradiotherapy (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> has shown promising complete response with less phototoxicity and shorter sun shade period. In addition, the efficacy and safety of <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> in patients with local failure of <jats:styled-content style=\"fixed-case\">ESCC<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> were shown in several clinical trials. The direction of the study interest of the next\u2010generation <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> is the safety and potential expansion of the indications for its application in the future. This review covers the <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> for the treatment of <jats:styled-content style=\"fixed-case\">ESCC<\/jats:styled-content> and dysplastic Barrett's esophagus, with special focus on the role of <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> in practice for esophageal cancer.<\/jats:p>","DOI":"10.1111\/den.13353","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T23:37:55Z","timestamp":1548286675000},"page":"508-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Role of photodynamic therapy in the treatment of esophageal cancer"],"prefix":"10.1111","volume":"31","author":[{"given":"Hao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou China"},{"name":"Department of Gastroenterology and Endoscopy National Cancer Center Hospital East Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsunori","family":"Minamide","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Endoscopy National Cancer Center Hospital East Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Endoscopy National Cancer Center Hospital East Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1071"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1894"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-018-2426-z"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000469675"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22802"},{"key":"e_1_2_12_8_1","first-page":"504","article-title":"Photodynamic therapy in the treatment of bladder cancer: past challenges and current innovations","volume":"4","author":"Railkar R","year":"2018","journal-title":"Eur. 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