{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:53:26Z","timestamp":1785261206635,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T00:00:00Z","timestamp":1563753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2020,3]]},"abstract":"Objectives<\/jats:title>The clinical success of per\u2010oral endoscopic myotomy (POEM<\/jats:styled-content>) has led to the development of a new field of \u2018submucosal endoscopy\u2019. This study aimed to evaluate the safety, efficacy, and limitations of per\u2010oral endoscopic tumor resection (POET<\/jats:styled-content>) in the management of submucosal tumors (SMT<\/jats:styled-content>s) in the esophagus and the gastric cardia.<\/jats:p><\/jats:sec>Methods<\/jats:title>POET<\/jats:styled-content> was performed in 47 patients from January 2011 to December 2017. The indication for POET<\/jats:styled-content> was SMT<\/jats:styled-content>s\u00a0\u2264\u00a030\u00a0mm in minor axis diameter. Patient and tumor characteristics (age, gender, tumor location, size, and histology), operative and clinical results of POET<\/jats:styled-content> (procedure time and completion rate, en bloc resection rate, length of hospitalization, adverse events and tumor recurrence) were analyzed retrospectively.<\/jats:p><\/jats:sec>Results<\/jats:title>POET<\/jats:styled-content> was successfully completed in 43 patients (91.5%) without any major adverse events (Clavien\u2010Dindo III<\/jats:styled-content>b\u2010IV<\/jats:styled-content>). Four patients required conversion to an open surgical procedure due to suboptimal visualization during POET<\/jats:styled-content>. Four patients underwent piecemeal resection of their SMT<\/jats:styled-content>s including GIST<\/jats:styled-content>s. Median follow\u2010up was 44\u00a0months (10\u201396\u00a0months), during that time, there were no incidences of tumor recurrence. Tumors that had a minor axis diameter\u00a0>\u00a030\u00a0mm or a tumor mass index (TMI<\/jats:styled-content>) [major axis diameter (mm)\u00a0\u00d7\u00a0minor axis diameter (mm)] >1000 had a high likelihood of being converted to surgical resection.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>POET<\/jats:styled-content> is a safe and effective treatment for SMT<\/jats:styled-content>s. However, in patients where the minor axis diameter is\u00a0>\u00a030\u00a0mm or the TMI<\/jats:styled-content>\u00a0>\u00a01000, surgical excision should be considered. Furthermore, application of POET<\/jats:styled-content> for SMT<\/jats:styled-content>s with malignant potential should be carefully considered to ensure optimal oncologic outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.13471","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T17:56:21Z","timestamp":1561485381000},"page":"328-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Clinical outcomes of per\u2010oral endoscopic tumor resection for submucosal tumors in the esophagus and gastric cardia"],"prefix":"10.1111","volume":"32","author":[{"given":"Manabu","family":"Onimaru","sequence":"first","affiliation":[{"name":"Digestive Diseases Center Showa University Koto Toyosu Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa University Koto Toyosu Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bechara","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa University Koto Toyosu Hospital Tokyo Japan"},{"name":"Gastroenterology and Advanced Therapeutic Endoscopy Queen's University Division of Gastroenterology Kingston General and Hotel Dieu Hospitals Kingston Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayo","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa University Koto Toyosu Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Raina Angeli","family":"Abad","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa University Koto Toyosu Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Ueno","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa University Koto Toyosu Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4107-9264","authenticated-orcid":false,"given":"Yuto","family":"Shimamura","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa University Koto Toyosu Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Sumi","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa University Koto Toyosu Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa University Koto Toyosu Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Ito","sequence":"additional","affiliation":[{"name":"Digestive Diseases Center Showa University Koto Toyosu Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(02)70085-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12149"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1004219"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-0679(03)00004-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.561364"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.10.082"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1244080"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1291659"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i2.578"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v8.i2.86"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-008-0798-7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20360"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/2303-9027.201086"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.11.044"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12422"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13239"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.139"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2017.09.002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-016-5350-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200001000-00008"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.01.040"},{"key":"e_1_2_8_24_1","first-page":"333","article-title":"Gastrointestinal stromal tumors of the esophagus: evaluation of a pooled case series regarding clinicopathological features and clinical outcome","volume":"5","author":"Lott S","year":"2015","journal-title":"Am. J. Cancer Res."}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.13471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.13471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/den.13471","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.13471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T05:29:38Z","timestamp":1694064578000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.13471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,22]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/den.13471"],"URL":"https:\/\/doi.org\/10.1111\/den.13471","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,22]]},"assertion":[{"value":"2019-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}