{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:44:39Z","timestamp":1778622279516,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2020,5]]},"abstract":"Background and Aim<\/jats:title>Gastric neoplasms (GN<\/jats:styled-content>), including gastric adenoma and carcinoma, are well known as extracolonic manifestations of familial adenomatous polyposis (FAP<\/jats:styled-content>). We aimed to investigate the clinicopathological features of GN<\/jats:styled-content> in FAP<\/jats:styled-content> patients and to clarify their relationship with the endoscopic status of the background mucosa.<\/jats:p><\/jats:sec>Methods<\/jats:title>We analyzed the records of 39 patients who were diagnosed with FAP<\/jats:styled-content> and underwent esophagogastroduodenoscopy between April 2005 and July 2016. Patients were divided into two groups according to atrophic gastritis (AG<\/jats:styled-content>) status. Endoscopic findings of GN<\/jats:styled-content> and background mucosa, and histopathological findings, including phenotypic expression of GN<\/jats:styled-content> and mutation locus of adenomatous polyposis coli (APC<\/jats:styled-content><\/jats:italic>) gene, were evaluated.<\/jats:p><\/jats:sec>Results<\/jats:title>Gastric neoplasms were more predominant in the AG<\/jats:styled-content>\u2010positive group than in the AG<\/jats:styled-content>\u2010negative group (6\/9, 66.7% vs<\/jats:italic> 7\/30, 23.3%; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.039). Of 36 GN<\/jats:styled-content> detected in 13 patients, six GN<\/jats:styled-content> in five patients were followed and 30 GN<\/jats:styled-content> in eight patients were endoscopically resected and analyzed. GN<\/jats:styled-content> in the AG<\/jats:styled-content>\u2010negative group frequently showed whitish color, were located in the proximal stomach, and presented the gastric immunophenotype compared to GN<\/jats:styled-content> in the AG<\/jats:styled-content>\u2010positive group. All GN<\/jats:styled-content> were intramucosal lesions and were curatively resected regardless of AG<\/jats:styled-content> status. APC<\/jats:styled-content><\/jats:italic> germline mutations were identified in 32 patients. In patients with GN<\/jats:styled-content>, a significantly higher number of mutation loci were among exons 10\u201315 (codons 564\u20131465).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Clinicopathological characteristics and phenotypic expressions of GN<\/jats:styled-content> in FAP<\/jats:styled-content> patients depend on background mucosa status with or without AG<\/jats:styled-content>. These findings are useful for detecting GN<\/jats:styled-content> in FAP<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.13512","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T13:58:28Z","timestamp":1565791108000},"page":"547-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Phenotypic variations of gastric neoplasms in familial adenomatous polyposis are associated with endoscopic status of atrophic gastritis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6364-1409","authenticated-orcid":false,"given":"Kaoru","family":"Nakano","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The Cancer Institute Hospital of Japanese Foundation for Cancer Research (JFCR) Tokyo Japan"},{"name":"Department of Pathology The Cancer Institute Hospital of Japanese Foundation for Cancer Research (JFCR) Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kawachi","sequence":"additional","affiliation":[{"name":"Department of Pathology The Cancer Institute Hospital of Japanese Foundation for Cancer Research (JFCR) Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Chino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Cancer Institute Hospital of Japanese Foundation for Cancer Research (JFCR) Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizuho","family":"Kita","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetic Oncology The Cancer Institute Hospital of Japanese Foundation for Cancer Research (JFCR) Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetic Oncology The Cancer Institute 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