{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:14:35Z","timestamp":1788826475075,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>\n                    There are no reports on detailed endoscopic diagnosis of superficial non\u2010ampullary duodenal epithelial tumors (SNADET) except for relatively small case series. Herein, we conducted a prospective observational study to investigate the relationship between endoscopic findings and histopathological diagnosis of SNADET. A total of 163 SNADET diagnosed using magnified endoscopic examination with image\u2010enhanced endoscopy (IEE\u2010ME) were prospectively registered in this study. We investigated location, size, macroscopic type, color, and IEE\u2010ME findings including surface structure (closed\u2010 or open\u2010loop) and presence of white opaque substance (WOS) in SNADET. We analyzed association between these findings and histopathological diagnosis of SNADET based on the Vienna classification (VCL) using logistic regression analysis. In univariate analysis, lesion size, superficial structure, and WOS deposition showed statistical significance, and the oral side of the lesion location showed statistical tendency for association with VCL C4\/5. In multivariate analysis, lesion size (odds ratio [OR], 2.92; 95% CI, 1.94\u20134.39;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) and negative WOS (OR, 5.59; 95% CI, 1.72\u201318.1;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) were significantly associated with VCL C4\/5 lesions. Superficial structures with a closed\u2010loop pattern on the surface showed statistical tendency for predicting VCL C4\/5 lesions (OR, 2.15; 95% CI, 0.86\u20135.37;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.10). Based on these findings, we concluded that negative WOS by IEE\u2010ME and lesion size were independent predictors of VCL C4\/5 SNADET. These factors may help us to understand of pathophysiology of SNADET and to select appropriate therapeutic strategies.\n                  <\/jats:p>","DOI":"10.1111\/den.13538","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T09:55:01Z","timestamp":1569232501000},"page":"417-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["How I do it: Endoscopic diagnosis for superficial non\u2010ampullary duodenal epithelial tumors"],"prefix":"10.1111","volume":"32","author":[{"given":"Atsushi","family":"Nakayama","sequence":"first","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7579-1316","authenticated-orcid":false,"given":"Motohiko","family":"Kato","sequence":"additional","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine Tokyo Japan"},{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusaku","family":"Takatori","sequence":"additional","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Shimoda","sequence":"additional","affiliation":[{"name":"Division of Pathology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine Tokyo Japan"},{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshiro","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Kiguchi","sequence":"additional","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Akimoto","sequence":"additional","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Mutaguchi","sequence":"additional","affiliation":[{"name":"Center for Diagnostic and Therapeutic Endoscopy Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Takabayashi","sequence":"additional","affiliation":[{"name":"Center for Diagnostic and Therapeutic Endoscopy Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadateru","family":"Maehata","sequence":"additional","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutoshi","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Kanai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohisa","family":"Yahagi","sequence":"additional","affiliation":[{"name":"Division of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13485"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199709000-00004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000217673.04165.ea"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.12.007"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.05.002"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.07.026"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13524"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13034"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13394"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i35.12673"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.02.018"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12277"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-113567"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12282"},{"key":"e_1_2_5_16_1","first-page":"S3","article-title":"The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1","volume":"2003","author":"[Anonymous]","year":"2002","journal-title":"Gastrointest. Endosc."},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.2.251"},{"key":"e_1_2_5_18_1","first-page":"462","article-title":"Endoscopic features of nonampullary duodenal tumors with narrow\u2010band imaging","volume":"57","author":"Yoshimura N","year":"2010","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_19_1","first-page":"1709","article-title":"Significance of magnifying endoscopy in diagnosis of duodenal elevated lesions","volume":"38","author":"Tanaka M","year":"2003","journal-title":"Stomach Intestine"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12331"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1327-0"}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.13538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.13538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/den.13538","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.13538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:29:25Z","timestamp":1694050165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.13538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,31]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/den.13538"],"URL":"https:\/\/doi.org\/10.1111\/den.13538","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,31]]},"assertion":[{"value":"2019-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}