{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:09:07Z","timestamp":1769155747424,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Capsule enteroscopy (CE) is recommended in the management of complicated celiac disease (CD). However, published data are derived from axial\u2010view capsule systems. No data are available on the use of lateral\/panoramic view capsules. This study aimed at evaluating the diagnostic yield and efficacy of the lateral\/panoramic versus the axial view capsule system in CD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive CD patients were enrolled in a prospective monocentric study. Each patient ingested an axial (PillCam SB3) and a lateral\/panoramic (CapsoCam Plus) view capsule with a 3\u2010h interval in a randomized order. Two experts blindly evaluated the CE carried out. A third expert reviewed the videos in cases of discordance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five CD patients were enrolled (four males, age at CE 51.2\u00a0\u00b1\u00a016.6\u00a0years, age at CD diagnosis 41.7\u00a0\u00b1\u00a020.6,\u00a0years on a gluten\u2010free diet [GFD] 9.6\u00a0\u00b1\u00a09.4). Indications at CE were refractory CD in nine cases, non\u2010responsiveness to GFD in 10 and GFD non\u2010compliance in six. A positive finding was evidenced in 15 (60%) and 13 (52%) cases by CapsoCam and PillCam respectively (not significant). Atrophy was detected by both capsules. Considering the percentage of the small\u2010bowel mucosa presenting atrophy signs, mean values were 22%\u00a0\u00b1\u00a035 and 20%\u00a0\u00b1\u00a029 for lateral\/panoramic and axial systems, respectively (not significant). Compared to duodenal histology, PillCam correctly identified 80% of patients with SB atrophy, whereas CapsoCam identified 73% of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lateral\/panoramic view CE is effective in the detection of small\u2010bowel atrophy in CD and presents good sensitivity and specificity when compared to histology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.13575","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T08:51:11Z","timestamp":1572857471000},"page":"778-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Small\u2010bowel capsule endoscopy in patients with celiac disease, axial versus lateral\/panoramic view: Results from a prospective randomized trial"],"prefix":"10.1111","volume":"32","author":[{"given":"Federica","family":"Branchi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Endoscopy Center for Prevention and Diagnosis of Celiac Disease Foundation IRCCS Ca\u2019 Granda Major Polyclinic Hospital Milan Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Ferretti","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Endoscopy Center for Prevention and Diagnosis of Celiac Disease Foundation IRCCS Ca\u2019 Granda Major Polyclinic Hospital Milan Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Orlando","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Endoscopy Center for Prevention and Diagnosis of Celiac Disease Foundation IRCCS Ca\u2019 Granda Major Polyclinic Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Eugenio","family":"Tontini","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Endoscopy Center for Prevention and Diagnosis of Celiac Disease Foundation IRCCS Ca\u2019 Granda Major Polyclinic Hospital Milan Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Penagini","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Endoscopy Center for Prevention and Diagnosis of Celiac Disease Foundation IRCCS Ca\u2019 Granda Major Polyclinic Hospital Milan Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Vecchi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Endoscopy Center for Prevention and Diagnosis of Celiac Disease Foundation IRCCS Ca\u2019 Granda Major Polyclinic Hospital Milan Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0873-0759","authenticated-orcid":false,"given":"Luca","family":"Elli","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Endoscopy Center for Prevention and Diagnosis of Celiac Disease Foundation IRCCS Ca\u2019 Granda Major Polyclinic Hospital Milan Italy"},{"name":"Department of Pathophysiology and Transplantation University of Milan Milan 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