{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:42:15Z","timestamp":1782301335751,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Anti\u2010reflux mucosectomy (ARMS) is a newfangled minimally invasive technique, with successful outcomes for the management of gastroesophageal reflux (GER). We present our initial experience (success rate) and safety profile for this procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with daily dependence on proton pump inhibitor (PPI) for GER were prospectively enrolled from September 2016 to August 2019 and underwent ARMS using a cap assisted endoscopic mucosal resection. Severity was assessed by gastroesophageal reflux disease questionnaire. Gastroscopy and 24\u2010h pH\u2010metry was done pre and post procedure. Patient characteristics, PPI requirement, adverse events and follow\u2010up were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010two patients [44 (71%) male] underwent successful ARMS with a mean age (SD) of 36 (9.9) years. Technical success was achieved in 100\u200a% of patients. Intraoperative bleeding was noted in 62 (100%) patients, endoscopic hemostasis was successfully achieved. At follow\u2010up dysphagia was seen in 5 (8%) patients which needed a single session of endoscopic dilation. At 2\u00a0months, mean (SD) DeMeester score normalized in 45 (72.5%) patients from 76.8 (18.3) to 14.3 (6.1) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). PPI could be stopped in 43 (69.4%) patients. The mean (SD) GERD\u2010Q score reduced from 10.6 (1.9) to 3.4 (1.5) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). However, in 12 (19.3%) patients low dose of PPIs was continued, while 7 (11.3%) patients continued full dose. Thirty\u2010eight (61.3%) patients telephonically reported symptomatic improvement and were off PPIs at 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anti\u2010reflux mucosectomy is safe and effective for treatment of GER. The long term outcomes are favorable, response is durable and promising at our center. Appropriate patient selection still remains primal to the overall success of ARMS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.13606","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T16:40:23Z","timestamp":1576255223000},"page":"745-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Feasibility and outcomes of anti\u2010reflux mucosectomy for proton pump inhibitor dependent gastroesophageal reflux disease: First Indian study (with video)"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9346-4343","authenticated-orcid":false,"given":"Gaurav","family":"Patil","sequence":"first","affiliation":[{"name":"Baldota Institute of Digestive Sciences Gleneagles Global Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5729-8897","authenticated-orcid":false,"given":"Ankit","family":"Dalal","sequence":"additional","affiliation":[{"name":"Baldota Institute of Digestive Sciences Gleneagles Global Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1687-4936","authenticated-orcid":false,"given":"Amit","family":"Maydeo","sequence":"additional","affiliation":[{"name":"Baldota Institute of Digestive Sciences Gleneagles Global Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68932-0"},{"key":"e_1_2_7_3_1","first-page":"118","article-title":"Gastroesophageal reflux disease: An emerging disease in Asia","volume":"2","author":"Goh KL","year":"2006","journal-title":"Gastroenterol. 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