{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:18:17Z","timestamp":1784715497448,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Few studies have directly compared the efficacy of sedated\u2010 and un\u2010sedated endoscopic variceal ligation (EVL) for acute variceal bleeding. We aimed to determine whether sedation during EVL in patients with variceal bleeding is safe and effective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed data from patients who underwent EVL for acute variceal bleeding according to sedation in six hospitals of Hallym University Medical Center. The primary endpoint was treatment failure, defined as a failure to control bleeding, death during EVL, or rebleeding within 5\u00a0days. Secondary endpoints included the procedure time, adverse events, and 30\u2010day mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1,300 patients who were included, only 430 (33.1%) received sedation during EVL. Propofol alone was used for sedation in 85% of sedated\u2010EVLs. The mean procedure time in the sedation group was shorter than that of the non\u2010sedation group (12.4\u00a0\u00b1\u00a09.5\u00a0min versus 13.8\u00a0\u00b1\u00a09.4\u00a0min, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.010). The proportion of treatment failure did not differ between the groups (7.4% versus 9.1%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.374). In the multivariable analysis, an AIMS65 score \u22652 and blood transfusion within 72\u00a0hours were associated with treatment failure of EVL; however, the use of sedation was not (odds ratio [95% confidence interval (CI)]\u00a0=\u00a00.96 [0.60\u20131.51]). Adverse events during EVL and hepatic encephalopathy did not differ between the two groups. Sedation also did not affect the 30\u2010day mortality (hazard ratio [95% CI]\u00a0=\u00a00.99 [0.66\u20131.47]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sedation reduced the procedure time of EVL. Sedation is safe to use during EVL for variceal bleeding in patients with cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.13610","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T03:21:13Z","timestamp":1576812073000},"page":"894-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical outcomes of sedation during emergency endoscopic band ligation for variceal bleeding: Multicenter cohort study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3824-3481","authenticated-orcid":false,"given":"Chan Hyuk","family":"Park","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hanyang University Guri Hospital Hanyang University College of Medicine Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1603-7468","authenticated-orcid":false,"given":"Se Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Hallym University College of Medicine Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Han","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Hallym University College of Medicine Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeong Guk","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Hallym University College of Medicine Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Hallym University College of Medicine Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Hallym University College of Medicine Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hyun","family":"In","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Hallym University College of Medicine Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Deok","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Hallym University College of Medicine Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000245"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12464"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.07.018"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00500.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328356ae49"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2012.07231.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117585"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.09.025"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520903194591"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05906.x"},{"key":"e_1_2_6_12_1","first-page":"612","article-title":"Upper gastrointestinal bleeding","volume":"22","author":"Martins NB","year":"2006","journal-title":"Curr. Opin. Gastroenterol."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2004.01.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000440715"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2013.19.2.105"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2016.0063"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-10-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-6553(88)90053-3"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.004"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29267"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200204000-00031"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.02.033"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.05.050"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21907"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309262"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2017.0064"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9617"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2014.29.1.57"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.023"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.06.024"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2018.72.4.188"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12341"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.313"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-2804-z"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-3133-y"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120529"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu555"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13423"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-925374"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3942-z"}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.13610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.13610","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/den.13610","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.13610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T19:38:45Z","timestamp":1693942725000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.13610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,12]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/den.13610"],"URL":"https:\/\/doi.org\/10.1111\/den.13610","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,12]]},"assertion":[{"value":"2019-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}