{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:13:25Z","timestamp":1790198005112,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study compared the safety and efficacy of peroral endoscopic myotomy for esophageal motility disorders between octogenarians and non\u2010octogenarians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective observational study recruited 321 patients (28 octogenarians and 293 non\u2010octogenarians) who underwent peroral endoscopic myotomy from two institutions. Clinical success (postoperative Eckardt score\u00a0\u2264\u00a03), technical success (completion of gastric and esophageal myotomy), and perioperative adverse events were compared between octogenarians and non\u2010octogenarians. Perioperative adverse events were classified into major and minor adverse events based on the International Peroral Endoscopic Myotomy Survey criteria and were subdivided into technical and non\u2010technical adverse events according to the presence of a direct causal relationship with the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in the rates of clinical success 1\u00a0year after treatment (100% vs. 97.3%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.64) and technical success (100% vs. 99.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.91) between octogenarians and non\u2010octogenarians. Octogenarians had a higher incidence of perioperative adverse events (28.6% vs. 10.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.00097), particularly major adverse events (25.0% vs. 3.0%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). There were no significant differences in the incidence of minor adverse events (7.1% vs. 7.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.67). Although there was no difference in the incidence of technical adverse events (10.7% vs. 9.2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.74), octogenarians had a significantly higher incidence of non\u2010technical adverse events (17.9% vs. 1.0%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There were no significant differences in short\u2010term clinical success and technical success between octogenarians and non\u2010octogenarians. However, octogenarians showed a significantly higher incidence of perioperative adverse events, particularly in major adverse events and non\u2010technical adverse events. Peroral endoscopic myotomy for octogenarians should be carefully applied.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.13686","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T06:46:40Z","timestamp":1586501200000},"page":"110-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of the safety and efficacy of peroral endoscopic myotomy between octogenarians and non\u2010octogenarians"],"prefix":"10.1111","volume":"33","author":[{"given":"Hirofumi","family":"Abe","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kobe University Graduate School of Medicine Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-8565","authenticated-orcid":false,"given":"Shinwa","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kobe University Graduate School of Medicine Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Kawara","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Konan Medical Center Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Toyonaga","sequence":"additional","affiliation":[{"name":"Department of Endoscopic Medicine Kobe University Hospital Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Ariyoshi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kobe University Graduate School of Medicine Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroya","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kobe University Graduate School of Medicine Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Sako","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kobe University Graduate School of Medicine Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Ikezawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kobe University Graduate School of Medicine Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzo","family":"Kodama","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Kobe University Graduate School of Medicine Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91428-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.196"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1244080"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1905380"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12450"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13083"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2017.02.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_8_11_1","first-page":"1001","article-title":"Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients","volume":"85","author":"Onodera T","year":"1984","journal-title":"Nippon Geka Gakkai Zasshi"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-2913-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05800-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doz022"},{"key":"e_1_2_8_15_1","unstructured":"Statistics Bureau of Japan.Population estimates [Internet].Tokyo:Statistics Bureau of Japan; c2019 [cited 2018 Oct 1]. 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