{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:47:41Z","timestamp":1787845661442,"version":"build-2784847793"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Spontaneous regression (SR) has been reported in various malignant tumors. However, SR in colorectal cancer (CRC) is particularly rare and the mechanism remains unclear. We here report three cases of CRCs displaying SR, which were experienced at two institutions. Intriguingly, all of these cases displayed the common endoscopic characteristics; superficial elevated lesion accompanied by a central depression (0\u2010IIa\u00a0+\u00a0IIc, in the Paris classification), with a nonpolypoid growth, located in the ascending colon. Furthermore, immunohistology of biopsy specimens revealed the lack of DNA mismatch repair proteins within the CRC lesions, suggesting that these were mismatch repair\u2010deficient (dMMR) CRCs. One of the major features of dMMR cancers is an increase in the number of tumor\u2010infiltrating lymphocytes. Thus, the dMMR phenotype might be associated with SR of CRCs through the activation of anti\u2010tumor host immune responses.<\/jats:p>","DOI":"10.1111\/den.13723","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T21:04:31Z","timestamp":1589663071000},"page":"190-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Spontaneous regression of mismatch repair\u2010deficient colorectal cancers: Case series"],"prefix":"10.1111","volume":"33","author":[{"given":"Takahiro","family":"Utsumi","sequence":"first","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin'ichi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kyoto University Graduate School of 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