{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:14:39Z","timestamp":1778645679414,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T00:00:00Z","timestamp":1601251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Post\u2010endoscopic retrograde cholangiopancreatography (ERCP) acute pancreatitis (PEP) is a frequent complication of this endoscopic procedure. Chronic statin intake has been linked to lower incidence and severity of acute pancreatitis (AP). Periprocedural rectal administration of non\u2010steroidal anti\u2010inflammatory drugs is protective against PEP, but the role of chronic acetylsalicylic acid (ASA) treatment is unclear. We aimed to investigate whether statins and chronic ASA intake are associated with lower risk of PEP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An international, multicenter, prospective cohort study. Consecutive patients undergoing ERCP in seven European centers were included. Patients were followed\u2010up to detect those with PEP. Multivariate analysis by means of binary logistic regression was performed, and adjusted odds ratios (aORs) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1150 patients were included, and 70 (6.1%) patients developed PEP. Among statins users, 8.1% developed PEP vs. 5.4% among non\u2010users (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.09). Multivariate analysis showed no association between statin use and PEP incidence (aOR 1.68 (95% CI 0.94\u20132.99, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.08)). Statin use had no effect on severity of PEP, being mild in 92.0% of statin users vs. 82.2% in non\u2010statin users (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.31). Chronic ASA use was not associated with PEP either (aOR 1.02 (95% CI 0.49\u20132.13), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.96). Abuse of alcohol and previous endoscopic biliary sphincterotomy were protective factors against PEP, while &gt;1 pancreatic guidewire passage, normal bilirubin values, and duration of the procedure &gt;20\u00a0minutes, were risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of statins or ASA is not associated with a lower risk or a milder course of PEP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.13801","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T03:34:33Z","timestamp":1595734473000},"page":"639-647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Chronic use of statins and acetylsalicylic acid and incidence of post\u2010endoscopic retrograde cholangiopancreatography acute pancreatitis: A multicenter, prospective, cohort study"],"prefix":"10.1111","volume":"33","author":[{"given":"Karina","family":"C\u00e1rdenas\u2010Ja\u00e9n","sequence":"first","affiliation":[{"name":"Gastroenterology Department Alicante University General Hospital Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Archibugi","sequence":"additional","affiliation":[{"name":"Pancreato\u2010Biliary Endoscopy and Endosonography Division Pancreas Translational &amp; Clinical Research Center San Raffaele Scientific Institute IRCCS Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran","family":"Poropat","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Faculty of Medicine Clinical Hospital Center of Rijeka University of Rijeka Rijeka Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taija","family":"Korpela","sequence":"additional","affiliation":[{"name":"Gastroenterological Surgery Abdominal Center Helsinki University Hospital University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Maisonneuve","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biostatistics IEO European Institute of Oncology IRCCS Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2245-4006","authenticated-orcid":false,"given":"Jose R.","family":"Aparicio","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Alicante University General Hospital Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Udd","sequence":"additional","affiliation":[{"name":"Gastroenterological Surgery Abdominal Center Helsinki University Hospital University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davor","family":"Stimac","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Faculty of Medicine Clinical Hospital Center of Rijeka University of Rijeka Rijeka Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo G.","family":"Arcidiacono","sequence":"additional","affiliation":[{"name":"Pancreato\u2010Biliary Endoscopy and Endosonography Division Pancreas Translational &amp; Clinical Research Center San Raffaele Scientific Institute IRCCS Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niccol\u00f2","family":"De Pretis","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Medicine Pancreas Center University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Valente","sequence":"additional","affiliation":[{"name":"Gastrocentrum Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Di Giulio","sequence":"additional","affiliation":[{"name":"Digestive and Liver Disease Unit S. Andrea Hospital Sapienza University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Casellas","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Alicante University General Hospital Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena","family":"Kyl\u00e4np\u00e4\u00e4","sequence":"additional","affiliation":[{"name":"Gastroenterological Surgery Abdominal Center Helsinki University Hospital University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goran","family":"Hauser","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Faculty of Medicine Clinical Hospital Center of Rijeka University of Rijeka Rijeka Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Mariani","sequence":"additional","affiliation":[{"name":"Pancreato\u2010Biliary Endoscopy and Endosonography Division Pancreas Translational &amp; Clinical Research Center San Raffaele Scientific Institute IRCCS Vita\u2010Salute San Raffaele University Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Gabbrielli","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Medicine Pancreas Center University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"L\u00f6hr","sequence":"additional","affiliation":[{"name":"Gastrocentrum Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7280-1761","authenticated-orcid":false,"given":"Giuseppe","family":"Vanella","sequence":"additional","affiliation":[{"name":"Digestive and Liver Disease Unit S. Andrea Hospital Sapienza University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Rainio","sequence":"additional","affiliation":[{"name":"Gastroenterological Surgery Abdominal Center Helsinki University Hospital University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Brozzi","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Medicine Pancreas Center University of Verona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urban","family":"Arnelo","sequence":"additional","affiliation":[{"name":"Gastrocentrum Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Fagerstr\u00f6m","sequence":"additional","affiliation":[{"name":"Gastrocentrum Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Capurso","sequence":"additional","affiliation":[{"name":"Pancreato\u2010Biliary Endoscopy and Endosonography Division Pancreas Translational &amp; Clinical Research Center San Raffaele Scientific Institute IRCCS Vita\u2010Salute San Raffaele University Milan Italy"},{"name":"Digestive and Liver Disease Unit S. Andrea Hospital Sapienza University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-9541","authenticated-orcid":false,"given":"Enrique","family":"de\u2010Madaria","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Alicante University General Hospital Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.08.063"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1377875"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1111103"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01279.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13311"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-018-0837-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.12.040"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3283453e41"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.396"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v5.i3.191"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618781168"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.8439"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306564"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2013.03.008"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00704"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hbpd.2019.10.001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2018.07.042"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302779"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(91)70740-2"},{"key":"e_1_2_8_22_1","article-title":"Statin consumption and risk of post\u2010endoscopic retrograde cholangiopancreatography pancreatitis","author":"Martinez\u2010Moneo E","journal-title":"Pancreatology"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1075-4080"},{"key":"e_1_2_8_24_1","article-title":"Regular statin use and incidence of postendoscopic retrograde cholangiopancreatography pancreatitis","author":"Hakuta R","journal-title":"J Clin Gastroenterol."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499138"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.60"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-925447"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.117550"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.11.020"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.136"},{"key":"e_1_2_8_31_1","first-page":"E1","article-title":"History of post\u2010endoscopic retrograde cholangiopancreatography pancreatitis and acute pancreatitis as risk factors for post\u2010ERCP pancreatitis","volume":"63","author":"Funatsu E","year":"2017","journal-title":"Kobe J Med Sci"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1256194"}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.13801","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.13801","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/den.13801","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.13801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T16:43:17Z","timestamp":1693154597000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.13801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,28]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/den.13801"],"URL":"https:\/\/doi.org\/10.1111\/den.13801","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,28]]},"assertion":[{"value":"2020-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}