{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:33:31Z","timestamp":1778114011451,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute pancreatitis is a major adverse event of endoscopic retrograde cholangiopancreatography (ERCP). Rectal administration of non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) decreases the incidence of post\u2010ERCP pancreatitis (PEP). However, the efficacy of low dose rectal NSAIDs for preventing PEP remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective study of 301 patients with native papilla and a body weight of &lt;50\u00a0kg who underwent ERCP between September 2010 and October 2019. After July 2016, a 25\u00a0mg dose of rectal diclofenac was routinely administered within 15\u00a0min before ERCP (NSAIDs group, <jats:italic>n<\/jats:italic>\u00a0=\u00a072) and the control group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0229) consisted of patients undergoing ERCP before this date without treatment. We compared the incidence of PEP between the two groups using propensity score matching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 66 pairs of patients in each group were selected. The patients and procedural\u2010related factors were similar in both groups. In total, 15 patients (11.4%) developed PEP: 12.1% (8\/66) in the NSAIDs group and 10.6% (7\/66) in the control group (Odds ratio (OR) 1.2; 95% confidence interval (CI) 0.4\u20133.5; <jats:italic>P\u00a0<\/jats:italic>=\u00a00.78). There was no significant difference in incidence of other adverse events related to ERCP between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prophylactic administration of a 25\u00a0mg dose of rectal diclofenac did not reduce the incidence of PEP in patients with a native papilla and a body weight of &lt;50\u00a0kg in this study and a certain dose of rectal NSAIDs, such as a 100\u2010mg dose, should be administered regardless of body weight to prevent PEP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.13828","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T20:06:43Z","timestamp":1599077203000},"page":"656-662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy of low dose rectal diclofenac for preventing post\u2010endoscopic retrograde cholangiopancreatography pancreatitis: Propensity score\u2010matched analysis"],"prefix":"10.1111","volume":"33","author":[{"given":"Takeshi","family":"Tomoda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Hospital  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironari","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Hospital  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Hospital  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0923-6143","authenticated-orcid":false,"given":"Akihiro","family":"Matsumi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Hospital  Okayama 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