{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:59:17Z","timestamp":1747184357262,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Management of diminutive pharyngeal neoplasms is controversial. Thus, we conducted a single\u2010center, prospective pilot study to investigate the efficacy and safety of endoscopic excision with cold forceps biopsy (CFB) of these lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Thirty\u2010nine lesions endoscopically diagnosed with narrow\u2010band imaging as pharyngeal neoplasms of 3\u00a0mm or smaller were excised with CFB using jumbo biopsy forceps (cap diameter 2.8\u00a0mm, jaw volume 12.4\u00a0mm<jats:sup>3<\/jats:sup>). The primary outcome was endoscopically determined local remnant\/recurrence rate 3\u00a0months after CFB. The secondary outcomes were histopathologically determined local remnant\/recurrence rate; risk factors associated with the endoscopic remnant\/recurrence; and incidence of intraoperative or delayed bleeding and other adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histological diagnosis of the 39 CFB\u2010excised lesions were: 11 high\u2010grade dysplasia (28.2%), 22 low\u2010grade dysplasia (56.4%), two basal cell hyperplasia (5.1%) and four atypical squamous epithelium (10.3%).Twenty\u2010seven patients (30 lesions) underwent follow\u2010up endoscopy 3\u00a0months after CFB; the endoscopic and pathological local remnant\/recurrence rate was 20% (6\/30; 95% confidence interval (CI), 7.7\u201336.6%) and 16.7% (5\/30; 95%\u00a0CI, 5.6\u201334.7%), respectively. Location of the lesion in the hypopharynx was a significant risk factor associated with the endoscopic local remnant\/recurrence (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.049). No significant adverse events occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cold forceps biopsy with jumbo biopsy forceps appears to be a safe and effective technique for excising diminutive pharyngeal neoplasms. Although small, the excised lesions may have a remarkably high frequency of high\u2010grade dysplasia. (Clinical trial registration number: UMIN000037980).<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.13838","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T07:16:30Z","timestamp":1600672590000},"page":"761-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of cold forceps biopsy for diminutive pharyngeal neoplasms: Single\u2010center, prospective pilot study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9603-1896","authenticated-orcid":false,"given":"Yuichi","family":"Shimodate","sequence":"first","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Itakura","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Sunami","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Ueno","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daichi","family":"Hira","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Takayama","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Sumiya","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Sue","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rio","family":"Takezawa","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Doi","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Mouri","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Matsueda","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motowo","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Departments of Department of Gastroenterology and Hepatology Kurashiki Central Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20482"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2787-y"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12125"},{"key":"e_1_2_7_5_1","first-page":"1299","article-title":"Endoscopic diagnosis of superticial pharygeal cancer","volume":"106","author":"Momma K","year":"2009","journal-title":"Jpn J Gastroenterol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1013-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.3736"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.06.021"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.10.038"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.08.019"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12746"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13445"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-861352"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-016-0527-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.1997.tb00453.x"},{"volume-title":"World Health Organization classifications Tumours. International Agency for Research on Cancer (IARC) Pathology and Genetics of Head and Neck Tumours","year":"2005","author":"Barnes L","key":"e_1_2_7_16_1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03512.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12440"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i44.6468"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.4680"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12252"}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.13838","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.13838","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/den.13838","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.13838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T09:11:19Z","timestamp":1693213879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.13838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/den.13838"],"URL":"https:\/\/doi.org\/10.1111\/den.13838","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"type":"print","value":"0915-5635"},{"type":"electronic","value":"1443-1661"}],"subject":[],"published":{"date-parts":[[2020,10,27]]},"assertion":[{"value":"2020-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}