{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:56:28Z","timestamp":1789419388109,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>There are few reports on the long\u2010term prognosis of papillary tumors after endoscopic papillectomy. Here, we report a retrospective study of the therapeutic effects, long\u2010term prognosis, and affecting factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The inclusion criteria were papillary adenoma with\/without an adenocarcinoma component on biopsy results and \u226410\u00a0mm intraductal extension, and the exclusion criteria were moderate to poorly differentiated adenocarcinoma on biopsy results. If no residual lesion was confirmed \u22656\u00a0months after the last endoscopic treatment, remission was defined. Subsequently, follow\u2010up endoscopy was scheduled once a year. Surgery was required in the case of adenocarcinoma recurrence or intraductal lesions &gt;10\u00a0mm. The rates of adverse events, remission, recurrence, and need for surgery were examined. The affecting factors were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were a total of 253 subjects, including 65 with adenocarcinoma. Pancreatitis (7.5%), bleeding (9.1%) and perforation (2.8%) were observed as adverse events. Among 221 subjects with \u22656\u00a0months of follow\u2010up, 212 (95.9%) were in remission. The cumulative recurrence rate using the Kaplan\u2013Meier analysis at 5\u00a0years was 16.9% (22 cases), with the need for surgery in 5.9% (5 cases). Intraductal extension on preoperative diagnosis was the only significant risk factor for both recurrence (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and the need for surgery (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.005). The presence of adenocarcinoma had no significant effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although remission was achieved in more than 95% of our patients, we observed a high rate of recurrence at the long\u2010term follow\u2010up, which was significantly associated with intraductal extension but not with the presence of adenocarcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.13881","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T21:10:46Z","timestamp":1603746646000},"page":"858-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Endoscopic papillectomy for ampullary adenoma and early adenocarcinoma: Analysis of factors related to treatment outcome and long\u2010term prognosis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3720-781X","authenticated-orcid":false,"given":"Hiroki","family":"Kawashima","sequence":"first","affiliation":[{"name":"Department of Endoscopy Nagoya University Hospital  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7730-4630","authenticated-orcid":false,"given":"Eizaburo","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of 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