{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:35:13Z","timestamp":1790778913771,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Ulcerative colitis\u2010associated neoplasias (UCAN) are often flat with an indistinct boundary from surrounding tissues, which makes differentiating UCAN from non\u2010neoplasias difficult. Pit pattern (PIT) has been reported as one of the most effective indicators to identify UCAN. However, regenerated mucosa is also often diagnosed as a neoplastic PIT. Endocytoscopy (EC) allows visualization of cell nuclei. The aim of this retrospective study was to demonstrate the diagnostic ability of combined EC irregularly\u2010formed nuclei with PIT (EC\u2010IN\u2010PIT) diagnosis to identify UCAN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study involved patients with ulcerative colitis whose lesions were observed by EC. Each lesion was diagnosed by two independent expert endoscopists, using two types of diagnostic strategies: PIT alone and EC\u2010IN\u2010PIT. We evaluated and compared the diagnostic abilities of PIT alone and EC\u2010IN\u2010PIT. We also examined the difference in the diagnostic abilities of an EC\u2010IN\u2010PIT diagnosis according to endoscopic inflammation severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed 103 lesions from 62 patients; 23 lesions were UCAN and 80 were non\u2010neoplastic. EC\u2010IN\u2010PIT diagnosis had a significantly higher specificity and accuracy compared with PIT alone: 84% versus 58% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and 88% versus 67% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), respectively. The specificity and accuracy were significantly higher for Mayo endoscopic score (MES) 0\u20131 than MES 2\u20133: 93% versus 68% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and 95% versus 74% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our novel EC\u2010IN\u2010PIT strategy had a better diagnostic ability than PIT alone to predict UCAN from suspected and initially detected lesions using conventional colonoscopy. UMIN clinical trial (UMIN000040698).<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.13964","type":"journal-article","created":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T11:26:51Z","timestamp":1614511611000},"page":"133-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Combined endocytoscopy with pit pattern diagnosis in ulcerative colitis\u2010associated neoplasia: Pilot study"],"prefix":"10.1111","volume":"34","author":[{"given":"Shin\u2010ei","family":"Kudo","sequence":"first","affiliation":[{"name":"Digestive Disease Center Showa University Northern Yokohama Hospital Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Maeda","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Showa University Northern Yokohama Hospital Kanagawa 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