{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:59:31Z","timestamp":1747184371184,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hodgkin\u2019s lymphoma (HL) survivors treated with abdominal radiotherapy and\/or procarbazine have an increased risk of developing colorectal neoplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We evaluated the clinicopathological characteristics and risk factors for developing (advanced) neoplasia (AN) in HL survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In all, 101 HL survivors (median age 51\u2009years, median age of HL diagnosis 25\u2009years) underwent colonoscopy and 350 neoplasia and 44 AN (classified as advanced adenomas\/serrated lesions or colorectal cancer), mostly right\u2010sided, were detected, as published previously. An average\u2010risk asymptomatic cohort who underwent screening colonoscopy were controls (median age 60\u2009years). Clinicopathological characteristics of AN were evaluated in both groups. Mismatch repair (MMR) status was assessed using immunohistochemistry (MLH1\/MSH2\/MSH6\/PMS2). Logistic regression analysis was performed to evaluate the risk factors for AN in HL survivors, including age at HL diagnosis and interval between HL and colonoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 101 colonoscopies in HL survivors, AN was primarily classified based on polyp size \u226510\u2009mm, whereas (high\u2010grade)dysplasia was more often seen in AN in controls. An interval between HL diagnosis and colonoscopy &gt;26\u2009years was associated with more AN compared with an interval of &lt;26\u2009years, with an odds ratio for AN of 3.8 (95% confidence interval 1.4\u20139.1) (<jats:italic>p &lt;<\/jats:italic>\u20090.01). All 39 AN that were assessed were MMR proficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Colorectal neoplasia in HL survivors differ from average\u2010risk controls; classification AN was primarily based on polyp size (\u226510\u2009mm) in HL survivors. Longer follow\u2010up between HL diagnosis and colonoscopy was associated with a higher prevalence of AN in HL survivors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14004","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T07:42:50Z","timestamp":1619768570000},"page":"163-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinicopathological features and risk factors for developing colorectal neoplasia in Hodgkin\u2019s lymphoma survivors"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-7986","authenticated-orcid":false,"given":"Berbel L. M.","family":"Ykema","sequence":"first","affiliation":[{"name":"Department of <sup>1<\/sup>Gastroenterology and Hepatology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1894-3440","authenticated-orcid":false,"given":"Lisanne S.","family":"Rigter","sequence":"additional","affiliation":[{"name":"Department of <sup>1<\/sup>Gastroenterology and Hepatology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9103-9757","authenticated-orcid":false,"given":"Manon C. W.","family":"Spaander","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus Medical Center University Hospital Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6913-9954","authenticated-orcid":false,"given":"Leon M. G.","family":"Moons","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7976-7949","authenticated-orcid":false,"given":"Tanya M.","family":"Bisseling","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2306-6590","authenticated-orcid":false,"given":"Berthe M. P.","family":"Aleman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4363-0745","authenticated-orcid":false,"given":"Evelien","family":"Dekker","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Amsterdam University Medical Centers Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wieke H. M.","family":"Verbeek","sequence":"additional","affiliation":[{"name":"Department of <sup>1<\/sup>Gastroenterology and Hepatology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0633-3098","authenticated-orcid":false,"given":"Ernst J.","family":"Kuipers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus Medical Center University Hospital Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6218-6128","authenticated-orcid":false,"given":"Jan Paul","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6735-8651","authenticated-orcid":false,"given":"Pieternella J.","family":"Lugtenburg","sequence":"additional","affiliation":[{"name":"Department of <sup>8<\/sup>Hematology Erasmus MC Cancer Institute Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3860-8698","authenticated-orcid":false,"given":"Cecile P. 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