{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:37:36Z","timestamp":1792471056695,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The usefulness of endoscopic and histological risk assessment for gastric cancer (GC) has not been fully investigated in Japanese clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multicenter observation study, GC and non\u2010GC patients were prospectively enrolled in 10 Japanese facilities. The Kyoto classification risk scoring system, the Kimura\u2013Takemoto endoscopic atrophy classification, the endoscopic grading of gastric intestinal metaplasia (EGGIM), the operative link on gastritis assessment (OLGA) and the operative link on gastric intestinal metaplasia assessment (OLGIM) were applied to all patients. The strength of an association with GC risk was compared. In addition, important endoscopic findings in the Kyoto classification were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 115 GC and 265 non\u2010GC patients were analyzed. Each risk stratification method had a significant association with GC risk in univariate analysis. In multivariate analysis, OLGIM stage III\/IV (odds ratio [OR] 2.8 [95% CI 1.5\u20135.3]), high EGGIM score (OR 1.8 [1.0\u20133.1]) and opened\u2010type Kimura\u2013Takemoto (OR 2.5 [1.4\u20134.5]) had significant associations with GC risk. In the Kyoto classification, opened\u2010type endoscopic atrophy, invisible regular arrangement of collecting venules (RAC), extensive (&gt;30%) intestinal metaplasia in the corpus in image\u2010enhanced endoscopy, and map\u2010like redness in the corpus were independent high\u2010risk endoscopic findings. The modified Kyoto classification risk scoring system using these four findings demonstrated a better area under the receiver operating characteristic curve value (0.750, <jats:italic>P<\/jats:italic>\u2009=\u20090.052) than that of the original Kyoto classification (0.706).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The OLGIM stage III\/IV, high EGGIM score and open\u2010typed Kimura\u2013Takemoto had strong association with GC risk in Japanese patients. The modified Kyoto classification risk scoring system may be useful for GC risk assessment, which warrants further validation. (UMIN000027023).<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14114","type":"journal-article","created":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T12:41:32Z","timestamp":1629463292000},"page":"508-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Kyoto classification risk scoring system and endoscopic grading of gastric intestinal metaplasia for gastric cancer: Multicenter observation study in Japan"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8312-732X","authenticated-orcid":false,"given":"Masashi","family":"Kawamura","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Sendai City Hospital Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriya","family":"Uedo","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Osaka International Cancer Institute Osaka 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