{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:52:56Z","timestamp":1785538376150,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K08362"],"award-info":[{"award-number":["JP19K08362"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Disconnected pancreatic duct syndrome (DPDS) frequently occurs in patients with acute necrotizing pancreatitis and resultant pancreatic fluid collection (PFC). We performed a systematic review and meta\u2010analysis to evaluate outcomes of endoscopic ultrasound\u2010guided treatment of PFCs according to the presence of DPDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using PubMed, Embase, and the Cochrane database, we identified clinical studies published until January 2021 with data comparing outcomes of endoscopic ultrasound\u2010guided drainage of PFCs between DPDS and non\u2010DPDS patients. We pooled data on technical and clinical success rates, PFC recurrence, and adverse events using the random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified five eligible articles including 941 PFC patients treated with endoscopic ultrasound\u2010guided interventions. Clinical success, defined as resolution of the PFC and symptoms, was achieved in a majority of the cases irrespective of DPDS (pooled odds ratio [OR] comparing DPDS to non\u2010DPDS patients, 0.77; 95% confidence interval [CI] 0.33\u20131.81). Compared to patients without DPDS, patients with DPDS were more likely to undergo PFC recurrence (pooled OR 6.72; 95% CI 2.72\u201316.6) after clinical resolution of PFC. Prolonged plastic stent placement following the clinical resolution was more frequently performed in DPDS patients than in non\u2010DPDS patients (pooled OR 15.9; 95% CI 2.76\u201391.9). No statistically significant difference was observed between the groups in terms of the rate of technical success, adverse events, or mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Disconnected pancreatic duct syndrome was associated with higher rate of PFC recurrence after successful endoscopic treatment of PFCs. Future studies should evaluate effectiveness and optimal duration of long\u2010term placement of transmural plastic stents for PFCs with DPDS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14142","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T19:12:36Z","timestamp":1632165156000},"page":"676-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Disconnected pancreatic duct syndrome and outcomes of endoscopic ultrasound\u2010guided treatment of pancreatic fluid collections: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-2755","authenticated-orcid":false,"given":"Tsuyoshi","family":"Hamada","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Hepato\u2010Biliary\u2010Pancreatic Medicine 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