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Currently available endoluminal anti\u2010reflux procedures include radiofrequency therapy (Stretta), suturing\/plication and mucosal ablation\/resection techniques at the gastroesophageal junction. Meticulous work up and patient selection results in a favorable outcome with these endoscopic therapies, especially the quality of life and partially the PPI independence. Stretta can be considered in patients with PPI refractory GERD and might have a role in patients with reflux hypersensitivity and functional heartburn. Endoscopic fundoplication using the Esophyx device and the GERD\u2010X device have strong evidence (multiple randomized controlled trials) in patients with small hiatus hernia and high volume reflux episodes. Mucosal resection\/ablation techniques like anti\u2010reflux mucosectomy and anti\u2010reflux mucosal ablation have shown promising results but need long term follow\u2010up studies to prove their efficacy. The subset of PPI dependent GERD population will benefit from endoscopic therapies and the future of endoscopic management of GERD looks promising.<\/jats:p>","DOI":"10.1111\/den.14169","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T18:41:49Z","timestamp":1634323309000},"page":"687-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Endoscopic management of gastroesophageal reflux disease: Panacea for proton pump inhibitors dependent\/refractory patients"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3203-7708","authenticated-orcid":false,"given":"Rakesh","family":"Kalapala","sequence":"first","affiliation":[{"name":"Asian Institute of Gastroenterology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Singla","sequence":"additional","affiliation":[{"name":"Asian Institute of 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