{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:36:30Z","timestamp":1791470190602,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","award":["203145Z\/16\/Z"],"award-info":[{"award-number":["203145Z\/16\/Z"]}],"id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","award":["203145Z\/16\/Z"],"award-info":[{"award-number":["203145Z\/16\/Z"]}],"id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>There is uncertainty regarding the efficacy of artificial intelligence (AI) software to detect advanced subtle neoplasia, particularly flat lesions and sessile serrated lesions (SSLs), due to low prevalence in testing datasets and prospective trials. This has been highlighted as a top research priority for the field.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An AI algorithm was evaluated on four video test datasets containing 173 polyps (35,114 polyp\u2010positive frames and 634,988 polyp\u2010negative frames) specifically enriched with flat lesions and SSLs, including a challenging dataset containing subtle advanced neoplasia. The challenging dataset was also evaluated by eight endoscopists (four independent, four trainees, according to the Joint Advisory Group on gastrointestinal endoscopy [JAG] standards in the UK).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the first two video datasets, the algorithm achieved per\u2010polyp sensitivities of 100% and 98.9%. Per\u2010frame sensitivities were 84.1% and 85.2%. In the subtle dataset, the algorithm detected a significantly higher number of polyps (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), compared to JAG\u2010independent and trainee endoscopists, achieving per\u2010polyp sensitivities of 79.5%, 37.2% and 11.5%, respectively. Furthermore, when considering subtle polyps detected by both the algorithm and at least one endoscopist, the AI detected polyps significantly faster on average.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The AI based algorithm achieved high per\u2010polyp sensitivities for advanced colorectal neoplasia, including flat lesions and SSLs, outperforming both JAG independent and trainees on a very challenging dataset containing subtle lesions that could have been overlooked easily and contribute to interval colorectal cancer. Further prospective trials should evaluate AI to detect subtle advanced neoplasia in higher risk populations for colorectal cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14187","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T17:34:43Z","timestamp":1636392883000},"page":"862-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Performance of artificial intelligence for detection of subtle and advanced colorectal neoplasia"],"prefix":"10.1111","volume":"34","author":[{"given":"Omer F.","family":"Ahmad","sequence":"first","affiliation":[{"name":"Wellcome\/EPSRC Centre for Interventional and Surgical Sciences University College London  London"},{"name":"Division of Surgery and Interventional Sciences University College London London UK"},{"name":"Gastrointestinal Services University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana","family":"Gonz\u00e1lez\u2010Bueno Puyal","sequence":"additional","affiliation":[{"name":"Wellcome\/EPSRC Centre for Interventional and Surgical Sciences University College London  London"},{"name":"Odin Vision Ltd  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Brandao","sequence":"additional","affiliation":[{"name":"Wellcome\/EPSRC Centre for Interventional and Surgical Sciences University College London  London"},{"name":"Odin Vision Ltd  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawen","family":"Kader","sequence":"additional","affiliation":[{"name":"Wellcome\/EPSRC Centre for Interventional and Surgical Sciences University College London  London"},{"name":"Division of Surgery and Interventional Sciences University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Sciences University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Hussein","sequence":"additional","affiliation":[{"name":"Wellcome\/EPSRC Centre for Interventional and Surgical Sciences University College London  London"},{"name":"Division of Surgery and Interventional Sciences University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehan J.","family":"Haidry","sequence":"additional","affiliation":[{"name":"Division of Surgery and Interventional Sciences University College London London UK"},{"name":"Gastrointestinal Services University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Toth","sequence":"additional","affiliation":[{"name":"Odin Vision Ltd  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mountney","sequence":"additional","affiliation":[{"name":"Odin Vision Ltd  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Seward","sequence":"additional","affiliation":[{"name":"Gastrointestinal Services University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roser","family":"Vega","sequence":"additional","affiliation":[{"name":"Gastrointestinal Services University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danail","family":"Stoyanov","sequence":"additional","affiliation":[{"name":"Wellcome\/EPSRC Centre for Interventional and Surgical Sciences University College London  London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence B.","family":"Lovat","sequence":"additional","affiliation":[{"name":"Wellcome\/EPSRC Centre for Interventional and Surgical Sciences University College London  London"},{"name":"Division of Surgery and Interventional Sciences University College London London UK"},{"name":"Gastrointestinal Services University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1201-7165"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15339"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13807"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1306-7590"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.03.019"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4037190"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patcog.2012.03.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compmedimag.2015.02.007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2017.2664042"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11548-013-0926-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.06.021"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.04.003"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.07.060"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0301-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50567-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319914"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231880"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30411-X"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2021.06.021"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13670"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.04.078"}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.14187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/den.14187","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.14187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T13:06:13Z","timestamp":1692882373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.14187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/den.14187"],"URL":"https:\/\/doi.org\/10.1111\/den.14187","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"2021-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}