{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:23:04Z","timestamp":1787314984428,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2022,5]]},"abstract":"\n Background and Aims<\/jats:title>\n Oral sodium sulfate (OSS) solution and low\u2010volume polyethylene glycol\u2010based solutions are two of the more common low\u2010volume purgatives used as colonoscopy preparations. Data on how these different low\u2010volume solutions compare are mixed. Our aim was to conduct a meta\u2010analysis of randomized controlled trials (RCTs) to compare OSS with low\u2010volume polyethylene glycol solutions (PEG) plus ascorbic acid (PEG\u2009+\u2009Asc) solution with respect to (i) satisfactory bowel preparation, (ii) excellent bowel preparation, and (iii) tolerability.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Studies were identified by searching 10 medical databases for reports published from 1974 until 2019. Only fully published RCTs comparing OSS and low\u2010volume PEG\u2010based products with regard to overall satisfactory bowel preparation were included. Pooling was conducted by both fixed\u2010effects and random effects models; results are presented from the random effects model when heterogeneity was significant.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seven studies (involving 2049 subjects) met the inclusion criteria. There was no difference between OSS and PEG\u2009+\u2009Asc with respect to adequate bowel preparation (risk ratio [RR] 1.02 [0.99\u20131.06];\n P<\/jats:italic>\n \u2009=\u20090.16). OSS did result in a higher chance of excellent bowel preparation (RR 1.18 [1.06\u20131.31];\n P<\/jats:italic>\n \u2009=\u20090.03). OSS was associated with a 30% increased risk of nausea (RR 1.35 [1.03\u20131.77];\n P<\/jats:italic>\n \u2009=\u20090.03) and more than double the risk of vomiting (RR 2.30 [1.63\u20132.23];\n P<\/jats:italic>\n \u2009<\u20090.05) compared with PEG\u2009+\u2009Asc. Begg's funnel plot indicated low probability of publication bias.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Individuals at low risk of inadequate bowel preparation who use OSS for bowel preparation are more likely to achieve excellent bowel preparation, but are more likely to experience nausea and vomiting than are individuals using low\u2010volume PEG\u2010based solutions.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/den.14194","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T09:55:47Z","timestamp":1637056547000},"page":"721-728","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Oral sulfate solution versus low\u2010volume polyethylene glycol for bowel preparation: Meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9173-7053","authenticated-orcid":false,"given":"Ijlal Akbar","family":"Ali","sequence":"first","affiliation":[{"name":"Digestive Diseases and Nutrition Division University of Oklahoma Health Sciences Center Oklahoma City OK USA"},{"name":"Veteran Affairs Medical Center Oklahoma City OK USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Roton","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The University of Oklahoma Health Sciences Center Oklahoma City OK USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9267-3023","authenticated-orcid":false,"given":"Mohammed","family":"Madhoun","sequence":"additional","affiliation":[{"name":"Digestive Diseases and Nutrition Division University of Oklahoma Health Sciences Center Oklahoma City OK USA"},{"name":"Veteran Affairs Medical Center Oklahoma City OK USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.03.1334"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)02776-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05827.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.77a.09122"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.389"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.25.050304.092647"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1569574"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13930"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.05.329"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000575"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.03.043"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000759"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2017.275"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000001137"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.03.1054"},{"key":"e_1_2_7_17_1","first-page":"4","article-title":"Bowel 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