{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:54:52Z","timestamp":1785538492511,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To generate a prognostic model based on a nomogram for adverse event (AE) prediction after lumen\u2010apposing metal stents (LAMS) placement in patients with pancreatic fluid collections (PFC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from a large multicenter series of PFCs treated with LAMS placement were retrieved. AE (overall and excluding mild events) prediction was calculated through a logistic regression model and a nomogram was created and internally validated after bootstrapping. Results were expressed in terms of odds ratio (OR) and 95% confidence interval (CI). Discrimination was assessed by c\u2010statistics and calibrated by comparing deciles of predicted and observed ORs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 516 patients were included (males 68%, mean age 61.6\u2009\u00b1\u200915.2\u2009years). PFCs were predominantly walled\u2010off necrosis (52.1%). Independent predictors of AE occurrence were injury of main pancreatic duct (OR in the case of leak 2.51, 95% CI 1.06\u20135.97, <jats:italic>P<\/jats:italic>\u2009=\u20090.03; OR in the case of complete disruption 2.61, 1.53\u20134.45, <jats:italic>P<\/jats:italic>\u2009=\u20090.01), abnormal vessels (OR in the case of perigastric varices 2.90, 1.31\u20136.42, <jats:italic>P<\/jats:italic>\u2009=\u20090.008; OR in the case of pseudoaneurysm 2.99, 1.75\u201311.93, <jats:italic>P<\/jats:italic>\u2009=\u20090.002), using a multigate technique (OR 3.00, 1.28\u20135.24; <jats:italic>P<\/jats:italic>\u2009=\u20090.05), and need of percutaneous drainage (OR 2.81, 1.03\u20137.65, <jats:italic>P<\/jats:italic>\u2009=\u20090.04). By nomogram, a score beyond 200 points corresponded to a 50% probability of AE occurrence. The model was confirmed even when excluding mild AEs and it showed optimal discrimination (c\u2010index 76.8%, 95% CI 74\u201379), confirmed after internal validation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with preprocedural evidence of pancreatic duct leak\/disruption, vessel alteration, requiring percutaneous drainage or a multigate technique are at higher risk for AE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14354","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T07:21:16Z","timestamp":1653290476000},"page":"1459-1470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Nomogram for prediction of adverse events after lumen\u2010apposing metal stent placement for drainage of pancreatic fluid collections"],"prefix":"10.1111","volume":"34","author":[{"given":"Antonio","family":"Facciorusso","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Department of Medical and Surgical Sciences University of Foggia  Foggia Italy"},{"name":"Gastroenterology and Digestive Endoscopy Unit, The Pancreas Institute G.B. Rossi University Hospital  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo","family":"Amato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Valduce Hospital  Como Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano Francesco","family":"Crin\u00f2","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, The Pancreas Institute G.B. Rossi University Hospital  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Sinagra","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit Fondazione Istituto G. Giglio  Cefal\u00f9 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Maida","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit S. Elia\u2010Raimondi Hospital  Caltanissetta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Fugazza","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit Humanitas Clinical and Research Center \u2013 IRCCS  Rozzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Binda","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit Forl\u00ec\u2010Cesena Hospitals, AUSL Romagna  Forl\u00ec\u2010Cesena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Repici","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit Humanitas Clinical and Research Center \u2013 IRCCS  Rozzano Italy"},{"name":"Department of Biomedical Sciences Humanitas University  Rozzano 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