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The major AEs comprise delayed bleeding (DB) and delayed perforation (DP), and overall AEs comprise DB plus DP. This review aimed to clarify the clinical efficacy and technical outcomes of endoscopic prophylactic closure for post\u2010ESD defects. We identified studies involving \u226510 patients up to March 2022 in which endoscopic closure was applied for gastric, duodenal, and colorectal post\u2010ESD defects. In the stomach, total rates of overall AEs and DB were significantly lower in the closure than non\u2010closure group. In the duodenum, total rates of overall AEs, DB, and DP were significantly lower in the closure group. In the colorectum, total rates of overall AEs and DB were significantly lower in the closure group. Closure techniques, categorized into three groups (clip\u2010based techniques, mechanical clipping, and surgical stitch\u2010based techniques), were illustrated. Endoscopic closure demonstrated a certain ability to reduce DB after gastric, duodenal, and colorectal ESD as well as DP after duodenal ESD. 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