{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:39:56Z","timestamp":1787312396487,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Polyethylene glycol (PEG) split\u2010dose regimen is recommended as the option of choice for colon preparation before colonoscopy in children and adults. Sodium picosulfate plus magnesium citrate (SPMC) is equally effective but better tolerated than PEG for bowel preparation before colonoscopy in children. The aim of this study was to assess the superiority of SPMC split\u2010dose regimen compared with SPMC day\u2010before regimen for bowel cleansing before colonoscopy in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a multicenter, randomized, single\u2010blind study. Pediatric inpatients undergoing colonoscopy received SPMC either in the day\u2010before dosing or in split dosing. Overall bowel cleansing was assessed using the Boston Bowel Preparation Scale (BBPS) and was rated as successful when BBPS was \u22656. Patient tolerability, acceptability, and compliance were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The rate of successful cleansing level was significantly higher in the split\u2010dose group than in the day\u2010before group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The BBPS scores were significantly higher in the split\u2010dose group than in the day\u2010before group for the whole colon (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), the right colon (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and transverse colon (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Patient acceptability was better in the split\u2010dose group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.0003;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.005). The percentage of children needing nasogastric tube placement was better in the split\u2010dose group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The split\u2010dose regimen of SPMC was superior to the day\u2010before regimen in terms of successful colon cleansing and acceptability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.14481","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T02:14:06Z","timestamp":1669083246000},"page":"606-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Split\u2010dose versus day\u2010before regimen of sodium picosulfate plus magnesium citrate for bowel cleansing before colonoscopy in children: Randomized controlled trial"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-7758","authenticated-orcid":false,"given":"Giovanni","family":"Di Nardo","sequence":"first","affiliation":[{"name":"NESMOS Department, Faculty of Medicine and Psychology Sapienza University of Rome, Sant'Andrea University Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Felici","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Children's Hospital Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo  Alessandria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Zenzeri","sequence":"additional","affiliation":[{"name":"NESMOS Department, Faculty of Medicine and Psychology Sapienza University of Rome, Sant'Andrea University Hospital  Rome Italy"},{"name":"Pediatric Unit, Children's Hospital Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo  Alessandria Italy"},{"name":"Emergency Pediatric Department Santobono\u2010Pausilipon Children's Hospital  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Mennini","sequence":"additional","affiliation":[{"name":"Translational Research in Pediatric Specialities Area, Allergy Unit, \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania","family":"Evangelisti","sequence":"additional","affiliation":[{"name":"NESMOS Department, Faculty of Medicine and Psychology Sapienza University of Rome, Sant'Andrea University Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Parisi","sequence":"additional","affiliation":[{"name":"NESMOS Department, Faculty of Medicine and Psychology Sapienza University of Rome, Sant'Andrea University Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Claudia","family":"Massolo","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Medical and Surgical Department of Fetus\u2010Newborn\u2010Infant, \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"Department of Gastroenterology IRCCS Humanitas Research Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Piccirillo","sequence":"additional","affiliation":[{"name":"NESMOS Department, Faculty of Medicine and Psychology Sapienza University of Rome, Sant'Andrea University Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Lucchini","sequence":"additional","affiliation":[{"name":"NESMOS Department, Faculty of Medicine and Psychology Sapienza University of Rome, Sant'Andrea University Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Furio","sequence":"additional","affiliation":[{"name":"NESMOS Department, Faculty of Medicine and Psychology Sapienza University of Rome, Sant'Andrea University Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Quatrale","sequence":"additional","affiliation":[{"name":"NESMOS Department, Faculty of Medicine and Psychology Sapienza University of Rome, Sant'Andrea University Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Strisciuglio","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialistic Surgery University of Campania \u201cLuigi Vanvitelli\u201d  Naples 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