{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:03:00Z","timestamp":1771563780169,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Low\u2010volume polyethylene glycol plus ascorbic acid (PEG\u2010Asc) reduces the dosage of colonoscopic bowel preparation (BP) solution, but is still poorly tolerated. Adding laxatives to the BP solution reduces the volume of fluid required, without affecting quality. This study aimed to compare 1\u00a0L PEG\u2010Asc plus 24\u2009mg senna (1L\u2010PEG\/AS) and conventional 2\u00a0L PEG\u2010Asc (2L\u2010PEG\/A) regimens on BP quality and patient tolerability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center, randomized, investigator\u2010blinded, noninferiority trial was performed between June and August 2022. Outpatients scheduled for colonoscopy were randomized (1:1) to the 1L\u2010PEG\/AS or 2L\u2010PEG\/A group. The Boston Bowel Preparation Scale (BBPS) was used to evaluate BP quality. Adverse events and tolerability were surveyed using questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 344 patients received 1L\u2010PEG\/AS or 2L\u2010PEG\/A regimens. The baseline characteristics and adverse events of the two groups were comparable. The 1L\u2010PEG\/AS group showed noninferior adequate BP rates compared with the 2L\u2010PEG\/A group (88% vs. 89%, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.00); overall BBPS was 7.1\u2009\u00b1\u20091.5 and 7.2\u2009\u00b1\u20091.5, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.39). Higher willingness to repeat the BP was observed in the 1L\u2010PEG\/AS group (85% vs. 62%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 1L\u2010PEG\/AS regimen was comparable to the 2L\u2010PEG\/A regimen in terms of BP adequacy, requiring lower BP solution volumes, with better patient tolerance. Thus, it may be a suitable alternative to the conventional BP solution for colonoscopy.<\/jats:p><jats:p>The Japan Registry of Clinical Trials (jRCT1051220043).<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14504","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T07:53:51Z","timestamp":1672041231000},"page":"767-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and tolerability of 1\u00a0L polyethylene glycol plus ascorbic acid with senna versus 2\u00a0L polyethylene glycol plus ascorbic acid for colonoscopic bowel preparation: Prospective, randomized, investigator\u2010blinded trial"],"prefix":"10.1111","volume":"35","author":[{"given":"Natsumi","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Minami Osaka Hospital  Osaka Japan"},{"name":"Department of Gastroenterology Osaka Metropolitan University Graduate School of Medicine  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