{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:18:08Z","timestamp":1770326288460,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Peroral endoscopic myotomy (POEM) is an effective treatment for esophageal motility disorders including achalasia and its variants. However, some surgeons have encountered challenging cases. This study aimed to develop a risk\u2010scoring system to predict challenging cases of POEM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients who underwent POEM between April 2015 and March 2020 at our hospital were included in this single\u2010center retrospective study. Challenging cases of POEM were defined as patients with any of the following: (i) procedure time \u226590\u2009min; (ii) mucosal perforation; (iii) pneumothorax; and (iv) major bleeding. A risk\u2010scoring system for predicting challenging cases was developed based on multivariate logistic regression and internal validation was performed using the bootstrap method. Clinical usefulness was evaluated using a decision curve analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 467 patients, 59 (12.6%) had challenging POEM. A risk\u2010scoring system consisted of four variables: duration of symptoms \u22655\u2009years (assigned score, 1 point), antithrombotics use (1 point), manometric diagnosis of achalasia variants (2 points), and dilation grade 3 (2 points). Our scoring system showed satisfactory discrimination (area under the receiver operating characteristic curve, 0.69; 95% confidence interval [CI] 0.61\u20130.77) and calibration (slope, 0.99; 95% CI 0.65\u20131.35). The decision curve analysis demonstrated its clinical usefulness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We established a risk\u2010scoring system to predict challenging cases of POEM. This scoring system may aid the selection of patients who require treatment from experienced surgeons.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14508","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T10:22:34Z","timestamp":1672050154000},"page":"729-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk\u2010scoring system for predicting challenging cases of peroral endoscopic myotomy"],"prefix":"10.1111","volume":"35","author":[{"given":"Tatsuya","family":"Nakai","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kobe University Graduate School of Medicine  Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kobe University Graduate School of Medicine  Hyogo 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