{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:05:16Z","timestamp":1787162716939,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Severe submucosal fibrosis is a crucial technical difficulty encountered during endoscopic submucosal dissection (ESD) in patients with ulcerative colitis (UC). We aimed to identify predictors of severe submucosal fibrosis in patients with UC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively included 55 tumors resected using ESD from 48 consecutive patients with UC. We analyzed the clinicopathological characteristics and treatment outcomes between the F0\/1 (none to mild submucosal fibrosis) group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928) and F2 (severe submucosal fibrosis) group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant difference was found between the F0\/1 and F2 groups in en bloc resection rate (100% vs. 96%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.49), the R0 resection rate (100% vs. 93%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.24), and the dissection speed (0.18 vs. 0.13\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      \/min,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.07). Intraoperative perforation was more common in the F2 group (30%) than in the F0\/1 group (8%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01). Multivariable analysis showed that a longer duration of UC (\u226510\u2009years; odds ratio [OR] 6.11; 95% confidence interval [CI] 1.20\u201331.03;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03) and scarring of background mucosa of the tumor (OR 39.61; 95% CI 3.91\u2013400.78;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) were independent predictors of severe submucosal fibrosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long UC duration and scarring background mucosa were predictors of severe submucosal fibrosis associated with perforation during ESD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.14570","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T04:39:23Z","timestamp":1681792763000},"page":"172-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Predictors of severe submucosal fibrosis during endoscopic submucosal dissection in patients with ulcerative colitis: Retrospective cohort study"],"prefix":"10.1111","volume":"36","author":[{"given":"Masafumi","family":"Nishio","sequence":"first","affiliation":[{"name":"Division of Endoscopy Yokohama City University Medical Center  Kanagawa Japan"},{"name":"Inflammatory Bowel Disease Center Yokohama City University Medical Center  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kingo","family":"Hirasawa","sequence":"additional","affiliation":[{"name":"Division of Endoscopy Yokohama City University Medical Center  Kanagawa 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