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According to the site of action along the gastrointestinal tract, EBMTs can be divided into two categories: gastric EBMTs, and small intestine\u2010targeted EBMTs. Unlike gastric EBMTs, which work through a volume\u2010restricting mechanism leading to early satiety and reduced caloric intake, small intestine\u2010targeted EBMTs can be metabolically beneficial through foregut and\/or hindgut pathways independent of weight loss, and therefore have great potential for the treatment of obesity\u2010related metabolic comorbidities such as type 2 diabetes. Although none of the small intestine\u2010targeted EBMTs have been approved by the US Food and Drug Administration to date, their clinical efficacy and safety have been extensively explored in investigational trials. This review aims to summarize and provide a comprehensive understanding of small intestine\u2010targeted EBMTs in clinical and preclinical settings, and to further discuss their potential mechanisms of action.<\/jats:p>","DOI":"10.1111\/den.14575","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T15:10:42Z","timestamp":1682176242000},"page":"684-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Small intestine\u2010targeted endoscopic bariatrics: Current status and future perspectives"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3807-4596","authenticated-orcid":false,"given":"Mengting","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou 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