{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:43:12Z","timestamp":1792082592783,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Endoscopic ultrasound\u2010guided radiofrequency ablation (EUS\u2010RFA) has been constantly increasing, particularly in the treatment of pancreatic neuroendocrine neoplasms (pNENs). While emerging data in this field are accumulating, we aimed to assess the pooled efficacy and safety of EUS\u2010RFA for pNENs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The PubMed\/Medline, Embase, and Cochrane Library databases search was conducted to identify studies reporting EUS\u2010RFA of pNENs with outcomes of interest (efficacy and safety). The primary outcome was radiological response. Efficacy was assessed by the pooled clinical response rate, whereas safety was assessed by the pooled adverse events (AEs) rate. Heterogeneity was assessed using <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>. Pooled estimates and the 95% confidence interval (CI) were calculated using a random\u2010effect model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven studies involving 292 patients were included. The pooled technical success rate was 99.2% (95% CI 97.9\u201399.9%), with no heterogeneity. The pooled complete radiological response was 87.1% (95% CI 80.1\u201392.8%). The pooled partial response was 11.4% (95% CI 6.2\u201318.1%). The pooled clinical response rate for functional pNENs was 94.9% (95% CI 90.7\u201397.9%), with no heterogeneity. The pooled incidence of AEs was 20.0% (95% CI 14.0\u201326.7%); most AEs were mild to moderate in grade, while the pooled incidence of severe AEs was 0.9% (95% CI 0.2\u20132.3%). The most common AEs were transient mild abdominal pain in 19 patients (6.5%), and mild to moderate pancreatitis in 23 patients (7.9%). No cases of mortality were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Endoscopic ultrasound\u2010guided radiofrequency ablation resulted on a feasible approach for pNENs treatment, with excellent technical success, high radiological and clinical response, and acceptable AE rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14681","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T09:05:25Z","timestamp":1694595925000},"page":"395-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Safety and efficacy of endoscopic ultrasound\u2010guided radiofrequency ablation for pancreatic neuroendocrine neoplasms: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6059-3854","authenticated-orcid":false,"given":"Tawfik","family":"Khoury","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wisam","family":"Sbeit","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Fusaroli","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Hospital of Imola University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Campana","sequence":"additional","affiliation":[{"name":"Department of Experimental, Diagnostic and Specialty Medicine Sant'Orsola\u2010Malpighi University Hospital, ENETS Center of Excellence  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Brighi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology IRCCS Romagna Institute for the Study of Tumors \u201cDino Amadori\u201d  Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Napoleon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Jean Mermoz Private Hospital, Ramsay Health  Lyon 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