{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:53:46Z","timestamp":1784249626389,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018254","name":"Japanese Foundation for Research and Promotion of Endoscopy","doi-asserted-by":"publisher","award":["Research Grant B \/ #1015"],"award-info":[{"award-number":["Research Grant B \/ #1015"]}],"id":[{"id":"10.13039\/100018254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>No comprehensive study has examined short\u2010 and long\u2010term adverse outcomes of endoscopic ultrasound (EUS)\u2010guided treatment of pancreatic fluid collections (PFCs) including walled\u2010off necrosis (WON) and pseudocysts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a multi\u2010institutional cohort of 357 patients receiving EUS\u2010guided treatment of PFCs (228 with WON and 129 with pseudocysts), we examined PFC type\u2010specific risk factors for procedure\u2010related adverse events (AEs), clinical failure, and recurrence. Odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs) were computed using the logistic and Cox regression models, respectively, adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adverse events were observed predominantly in WON, and risk factors were WON extension to the pelvis (OR 2.49; 95% CI 1.00\u20136.19) and endoscopic necrosectomy (OR 5.15; 95% CI 1.61\u201316.5). Risk factors for clinical failure in WON treatment included higher Charlson Comorbidity Index (OR for \u22653 vs. \u22642, 2.58; 95% CI 1.05\u20136.35), extension to the pelvis (OR 3.63; 95% CI 1.57\u20138.43), nonuse of a lumen\u2010apposing metal stent (OR 2.88; 95% CI 1.10\u20137.54), and percutaneous drainage (OR 3.73; 95% CI 1.27\u201310.9). Patients with pseudocysts extending to the paracolic gutter and the need for more than two endoscopic\/percutaneous procedures had ORs for clinical failure of 5.28 (95% CI 1.10\u201325.3) and 5.52 (95% CI 1.61\u201318.9), respectively. Pseudocysts requiring the multigateway approach were associated with a high risk of recurrence (HR 4.00; 95% CI 1.11\u201311.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The adverse outcomes at various phases of EUS\u2010guided PFC treatment may be predictable based on clinical parameters. Further research is warranted to optimize treatment strategies for high\u2010risk patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14683","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T09:42:32Z","timestamp":1694598152000},"page":"600-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Risk factors for adverse outcomes at various phases of endoscopic ultrasound\u2010guided treatment of pancreatic fluid collections: Data from a multi\u2010institutional consortium"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6008-1648","authenticated-orcid":false,"given":"Tomotaka","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine The University of Tokyo  Tokyo 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