{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:43:32Z","timestamp":1780105412704,"version":"3.54.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to clarify the clinical utility of measuring serum pancreatic enzymes after endoscopic retrograde cholangiopancreatography (ERCP) for the purpose of predicting post\u2010ERCP pancreatitis (PEP) by a meta\u2010analysis of diagnostic test accuracy studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Studies on the prediction accuracy of PEP by serum amylase or lipase measured at 2, 3, and 4\u2009h after ERCP were collected. A literature search was performed in PubMed and the Cochrane Library database for studies published between January 1980 and March 2023. The quality of individual studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies\u20102. Data were analyzed using Meta\u2010DiSc 2.0 software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We searched the databases and identified 20 observational studies (12,313 participants). PEPs were defined according to criteria by Cotton or modified Cotton, revised Atlanta criteria, or the Japanese criteria. Meta\u2010analysis of eight studies (4389 participants) showed a pooled sensitivity of 71.1% (95% confidence interval [CI] 56.1\u201382.5) and pooled specificity of 91.2% (95% CI 85.9\u201394.6) for the serum amylase cut\u2010off value at 3 times the upper limit of normal (ULN). Another meta\u2010analysis of five studies (1970 participants) showed a pooled sensitivity of 85.8% (95% CI 61.9\u201395.7) and pooled specificity of 85.3% (95% CI 81.9\u201388.1) for the serum lipase cut\u2010off value at 3 times ULN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite a high risk of bias due to various reference standards, this updated meta\u2010analysis and the utility assessment by a decision tree showed the utility of serum amylase or lipase levels more than 3 times ULN measured 2\u20134\u2009h after ERCP for predicting PEP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14718","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T09:26:14Z","timestamp":1699003574000},"page":"670-687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Postprocedure serum amylase or lipase levels predict postendoscopic retrograde cholangiopancreatography pancreatitis: Meta\u2010analysis of diagnostic test accuracy studies and utility assessment"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-0911","authenticated-orcid":false,"given":"Morihisa","family":"Hirota","sequence":"first","affiliation":[{"name":"Division of Gastroentrology Tohoku Medical and Pharmaceutical University  Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9433-8437","authenticated-orcid":false,"given":"Takao","family":"Itoi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Morizane","sequence":"additional","affiliation":[{"name":"Center of Gastroenterology and Inflammatory Bowel Disease Ofuna Chuo Hospital  Kanagawa 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