{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:56:07Z","timestamp":1788386167972,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007827","name":"American College of Gastroenterology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Endoscopic papillectomy (EP) is a minimally invasive therapy for the management of ampullary adenomas (AA). We conducted this multicenter study to assess the incidence of and factors related to the recurrence of AA after EP in patients with familial adenomatous polyposis (FAP) compared to sporadic AA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included patients who underwent EP for AA at 10 tertiary hospitals. Adenomatous tissue at the resection site at the time of surveillance endoscopies was considered recurrent disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 257 patients, 100 (38.9%) with FAP and 157 (61%) patients with sporadic AA, were included. Over a median of 31 (range, 11\u201361)\u2009months, recurrence occurred in 48\/100 (48%) of patients with FAP and 58\/157 (36.9%) with sporadic AA (<jats:italic>P<\/jats:italic>\u2009=\u20090.07). Two (2%) FAP patients and 10 (6.3%) patients with sporadic AA underwent surgery for recurrence. On multivariable regression analysis, the recurrence in FAP was higher than in sporadic patients after the first year of follow\u2010up. AA size (hazard ratio [HR] 1.03, 95% confidence interval [CI] 1.001, 1.056), periampullary extension (HR 2.5, 95% CI 1.5, 4.01), and biliary duct dilation (HR 2.04, 95% CI 1.2, 3.4) increased the risk, while en bloc resection (HR 0.6, 95% CI 0.41, 0.9) decreased the risk of recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recurrence rates are high after EP. Most recurrences in sporadic patients occur within the first year of follow\u2010up, but after the first year of follow\u2010up in patients with FAP. Recurrences are higher with larger adenomas, biliary duct dilation, and periampullary extensions, and may be mitigated by en bloc resection. These factors should be considered in decision\u2010making with the patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14725","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T22:40:18Z","timestamp":1700606418000},"page":"834-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Incidence and risk factors for recurrence of ampullary adenomas after endoscopic papillectomy: Comparative analysis of familial adenomatous polyposis and sporadic ampullary adenomas in an international multicenter cohort"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-1071","authenticated-orcid":false,"given":"Achintya D.","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic  Cleveland OH USA"},{"name":"Department of Gastroenterology and Hepatology, MetroHealth Medical Center Case Western Reserve University  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Cleveland Clinic  Cleveland OH USA"},{"name":"Department of Colorectal Surgery, Digestive Disease and Surgery Institute Cleveland Clinic  Cleveland OH USA"},{"name":"Sanford R. Weiss MD Center for Hereditary Colorectal Neoplasia, Digestive Disease and Surgery Institute Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter V.","family":"Draganov","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition University of Florida  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Bapaye","sequence":"additional","affiliation":[{"name":"Internal Medicine Rochester General Hospital  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Service Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saowanee","family":"Ngamruengphong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology The Johns Hopkins Hospital  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Kushnir","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Washington University School of Medicine  St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Interventional Oncology and Surgical Endoscopy (IOSE) Parkview Cancer Institute  Fort Wayne IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Kaul","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Rochester Medical Center  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparajita","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of California  San 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