{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:13:13Z","timestamp":1773839593186,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP16ck0106102"],"award-info":[{"award-number":["JP16ck0106102"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19ck0106276"],"award-info":[{"award-number":["JP19ck0106276"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The incidence of colorectal neuroendocrine tumors (NETs) has increased with colorectal cancer screening programs and increased colonoscopies. The management of colorectal NETs has recently shifted from radical surgery to endoscopic resection. We aimed to evaluate the short\u2010term outcomes of various methods of endoscopic resection for colorectal NETs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among those registered in the C\u2010NET STUDY, patients with colorectal NETs who underwent endoscopic treatment as the initial therapy were included. Short\u2010term outcomes, such as the en bloc resection rate and R0 resection (en bloc resection with tumor\u2010free margin) rate, were analyzed based on treatment modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 472 patients with 477 colorectal NETs received endoscopic treatment. Of these, 418 patients with 421 lesions who met the eligibility criteria were included in the analysis. The median age of the patients was 55\u2009years, and 56.9% of them were men. The lower rectum was the most commonly affected site (88.6%), and lesions &lt;10\u2009mm accounted for 87% of the cases. Endoscopic submucosal resection with a ligation device (ESMR\u2010L, 56.5%) was the most common method, followed by endoscopic submucosal dissection (ESD, 31.4%) and endoscopic mucosal resection using a cap (EMR\u2010C, 8.5%). R0 resection rates &lt;10\u2009mm were 95.5%, 94.8%, and 94.3% for ESMR\u2010L, ESD, and EMR\u2010C, respectively. All 16 (3.8%) patients who developed treatment\u2010related complications could be treated conservatively. Overall, 23 (5.5%) patients had incomplete resection without independent clinicopathological risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ESMR\u2010L, ESD, and EMR\u2010C were equally effective and safe for colorectal NETs with a diameter &lt;10\u2009mm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14728","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T23:10:09Z","timestamp":1700608209000},"page":"942-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Short\u2010term outcomes of endoscopic resection for colorectal neuroendocrine tumors: Japanese multicenter prospective C\u2010NET STUDY"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0916-5445","authenticated-orcid":false,"given":"Sayo","family":"Ito","sequence":"first","affiliation":[{"name":"Division of Endoscopy Shizuoka Cancer Center  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