{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T10:41:23Z","timestamp":1782470483031,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K08334"],"award-info":[{"award-number":["20K08334"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["21lk0201144h0001"],"award-info":[{"award-number":["21lk0201144h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Reflux hypersensitivity (RH) is a form of refractory gastroesophageal reflux disease in which duodenogastroesophageal reflux (DGER) plays a role. This study aimed to determine the usefulness of an endoscopy system equipped with image\u2010enhanced technology for evaluating DGER and RH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The image enhancement mode for detecting bilirubin and calculated values were defined as the Bil mode and Bil value, respectively. First, the visibility of the Bil mode was validated for a bilirubin solution and bile concentrations ranging from 0.01% to 100% (0.002\u201320\u2009mg\/dL). Second, visibility scores of the Bil mode, when applied to the porcine esophagus sprayed with a bilirubin solution, were compared to those of the blue laser imaging (BLI) and white light imaging (WLI) modes. Third, a clinical study was conducted to determine the correlations between esophageal Bil values and the number of nonacid reflux events (NNRE) during multichannel intraluminal impedance\u2010pH monitoring as well as the utility of esophageal Bil values for the differential diagnosis of RH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bilirubin solution and bile concentrations higher than 1% were visualized in red using the Bil mode. The visibility score was significantly higher with the Bil mode than with the BLI and WLI modes for 1% to 6% bilirubin solutions (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The esophageal Bil value and NNRE were significantly positively correlated (<jats:italic>P<\/jats:italic>\u2009=\u20090.031). The area under the receiver operating characteristic curve for the differential diagnosis of RH was 0.817.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Bil mode can detect bilirubin with high accuracy and could be used to evaluate DGER in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14749","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T06:34:55Z","timestamp":1703226895000},"page":"904-914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development of a new endoscopy system to visualize bilirubin for the diagnosis of duodenogastroesophageal reflux"],"prefix":"10.1111","volume":"36","author":[{"given":"Masafumi","family":"Wada","sequence":"first","affiliation":[{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University  Fukuoka 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