{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:23:08Z","timestamp":1775082188879,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We compared the efficacy and safety of transoral incisionless fundoplication (TIF) with the EsophyX2.0 and MUSE systems for treatment of gastroesophageal reflux disease (GERD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>TIF outcomes from prospective protocols (Esophy2.0X: 2007\u20132012; MUSE: 2015\u20132019) were retrospectively compared regarding technical success, moderate\/severe adverse events, morpho\u2010functional findings up to 1\u2009year, and clinical outcomes up to 3\u2009years. Inclusion criteria were: (i) at least 6\u2010month symptomatic GERD, full\/partial response to proton pump inhibitors (PPI), esophagitis, and nonerosive reflux disease\/hypersensitive esophagus (both protocols); (ii) hiatal hernia &lt;3\u2009cm (Esophy2.0X) and \u22642.5\u2009cm (MUSE); and (iii) Barrett's esophagus &lt;3\u2009cm (MUSE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the 50 EsophyX2.0 and 46 MUSE procedures, technical success and adverse event rates were similar, but MUSE\u2010related adverse events (4.4%) were life\u2010threatening. At 12\u2009months, hiatal hernia recurred more frequently after EsophyX2.0 (<jats:italic>P<\/jats:italic>\u2009=\u20090.008). At 6 months, significantly fewer total and acid refluxes were reported after both TIF, but not more significantly at 1 year. Symptoms improved after both TIF up to 1 year (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), but to a greater extent in MUSE patients up to 3\u2009years (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 vs. <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01 for EsophyX2.0). The rates of 3\u2010year off\u2010PPI therapy patients were 73.5% in the MUSE and 53.3% in the EsophyX2.0 series (<jats:italic>P<\/jats:italic>\u2009=\u20090.069).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although no conclusion could be drawn from this limited study, the MUSE technique seemed more effective in the long term in patients with hiatal hernia; however, there were more severe adverse events than with EsophyX2.0.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14810","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T08:40:57Z","timestamp":1717144857000},"page":"1232-1244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of EsophyX2.0 and MUSE systems for transoral incisionless fundoplication: Technical aspects and outcomes up to 3\u2009years"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0042-2583","authenticated-orcid":false,"given":"Sabrina Gloria Giulia","family":"Testoni","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Gastrointestinal Endoscopy IRCCS Ospedale San Raffaele  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Pantaleo","sequence":"additional","affiliation":[{"name":"UniSR\u2010Social.Lab, Faculty of Psychology Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Contu","sequence":"additional","affiliation":[{"name":"UniSR\u2010Social.Lab, Faculty of Psychology Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"Department of Social and Developmental Psychology \u201cLa Sapienza\u201d University  Rome 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