{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:40:26Z","timestamp":1774687226456,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"abstract":"<jats:p>Closure of mucosal defects following colorectal endoscopic submucosal dissection (C\u2010ESD) is often performed to prevent post\u2010C\u2010ESD adverse events. However, large mucosal defect closure using conventional clips remains technically challenging. Here, we evaluated the feasibility of the novel endoclip with anchor prongs, called the MANTIS Clip (Boston Scientific, Tokyo, Japan), for mucosal defect closure after C\u2010ESD. This high\u2010volume retrospective study was conducted at a single center. From March until December 2023, consecutive patients who underwent post\u2010C\u2010ESD mucosal defect closure using MANTIS Clip to achieve complete closure were enrolled. Patient clinical characteristics and outcomes were evaluated. Closure of the mucosal defect using the MANTIS Clip was attempted following C\u2010ESD in 32 lesions. The median sizes of the resection specimens and the tumors were 32\u2009mm (range, 17\u2013100\u2009mm) and 23.5\u2009mm (range, 5\u201396\u2009mm), respectively. The lesions were distributed between the cecum, ascending, transverse, descending, sigmoid, and rectum. Complete closure was achieved in 96.9% of cases (31\/32). All lesions up to 61\u2009mm in defect size were completely closed. The median closure time was 7.9 (range, 3.3\u201318.0) min. The median numbers of MANTIS Clip and additional conventional clips were 3 (range, 1\u20134) and 5 (range, 1\u201311), respectively. No adverse events associated with closure, post\u2010ESD bleeding, and delayed perforation occurred. MANTIS Clip closure for large post\u2010C\u2010ESD mucosal defects was found to be feasible and reliable with a high complete closure rate and a short procedure time.<\/jats:p>","DOI":"10.1111\/den.14891","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T06:19:53Z","timestamp":1722233993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel reopenable clip with anchor prongs facilitates mucosal defect closure after colorectal endoscopic submucosal dissection: Pilot feasibility study (with video)"],"prefix":"10.1111","author":[{"given":"Naoya","family":"Tada","sequence":"first","affiliation":[{"name":"Department of Endoscopy The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Tamai","sequence":"additional","affiliation":[{"name":"Department of Endoscopy The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Endoscopy The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Endoscopy The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Futakuchi","sequence":"additional","affiliation":[{"name":"Department of Endoscopy The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideka","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Department of Endoscopy The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakuni","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Endoscopy The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Sumiyama","sequence":"additional","affiliation":[{"name":"Department of Endoscopy The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.08.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-009-0562-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.13545"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0581-8886"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2019.1674918"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15148"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.03.051"},{"key":"e_1_2_9_9_1","first-page":"392","article-title":"Role of prophylactic hemoclip placement in prevention of delayed post\u2010polypectomy bleeding for large colon polyps: A meta\u2010analysis of randomized controlled trials","volume":"34","author":"Gangwani MK","year":"2021","journal-title":"Ann Gastroenterol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2020.10.004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","unstructured":"OgiyamaH KatoM YamaguchiSet\u00a0al.Efficacy of prophylactic clip closure in reducing the risk of delayed bleeding after colorectal endoscopic submucosal dissection in patients on anticoagulant therapy: Multicenter prospective study.Dig EndoscPublished online: 20 Feb 2024; 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