{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:35:47Z","timestamp":1790202947169,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202040079"],"award-info":[{"award-number":["202040079"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Municipal Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC12016109"],"award-info":[{"award-number":["SHDC12016109"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effects of endoscopic radiofrequency ablation (RFA) on proton pump inhibitor (PPI)\u2010dependent gastroesophageal reflux disease (GERD) in a Chinese population, and to explore the factors associated with favorable efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter, single\u2010armed prospective cohort study was conducted. PPI\u2010dependent GERD patients were enrolled and underwent RFA. The primary outcome was improvement of GERD health\u2010related quality of life (GERD\u2010HRQL). Secondary outcomes were symptom improvement, satisfaction, PPI use, and the indicators of 24\u2010h pH\u2010impedance monitoring. A nomogram to predict complete remission was constructed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 66 patients were included. The GERD\u2010HRQL score was significantly reduced at the 3\u2009month (mean difference, 14.7 [12.6\u201316.9]), 6\u2009month (mean difference, 15.9 [13.8\u201318.1]), 12\u2009month (mean difference, 16.7 [14.4\u201318.9]), 24\u2009month (mean difference, 18.4 [16.2\u201320.1]), 36\u2009month (mean difference, 18.2 [16.3\u201320.4]), and 48\u2009month follow\u2010up (mean difference, 16.1 [14.2\u201318.3]), all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001. The esophageal and extra\u2010esophageal symptom scores were all significantly decreased. The proportion of satisfaction and no PPI use were significantly higher. With regard to the indicators of 24\u2010h pH\u2010impedance monitoring, acid exposure time (AET), and DeMeester score, but not lower esophageal sphincter (LES) pressure, decreased significantly at the 12\u2009month follow\u2010up. A nomogram based on age, body mass index (BMI), baseline AET, and LES pressure was then constructed and showed good discrimination in the prediction of complete remission following RFA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated that RFA improved life quality as well as symptoms in PPI\u2010dependent GERD patients in a Chinese population. Younger age, higher BMI, lower baseline AET, and higher baseline LES pressure indicate favorable efficacy of RFA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.14963","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T06:14:48Z","timestamp":1733379288000},"page":"501-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of endoscopic radiofrequency ablation for proton pump inhibitor\u2010dependent gastroesophageal reflux disease: Multicenter prospective cohort study"],"prefix":"10.1111","volume":"37","author":[{"given":"Yuanxi","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Tongji Hospital\uff0cSchool of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tongji 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