{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:44:46Z","timestamp":1783691086107,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Conventional nodular gastritis has been known to be caused by <jats:italic>Helicobacter pylori<\/jats:italic> infection. Several cases of gastric mucosa\u2010associated lymphoid tissue (MALT) lymphoma with non\u2010<jats:italic>H. pylori Helicobacters<\/jats:italic> (NHPH) exhibit endoscopic findings resembling nodular gastritis. Considering the differences in malignancy, distinguishing between these two conditions is crucial. This study aimed to identify the distinguishing endoscopic features of NHPH\u2010induced gastric MALT lymphoma with nodular gastritis\u2010like appearance (NHPHi\u2010MNG) and <jats:italic>H.<\/jats:italic>\u2010induced conventional nodular gastritis (HPi\u2010NG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2011 and 2022, we analyzed 17 patients with NHPHi\u2010MNG and 50 patients with HPi\u2010NG at Hiroshima University Hospital and evaluated nodule morphology and distribution patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the HPi\u2010NG group, the NHPHi\u2010MNG group exhibited significantly larger nodules (2.5 vs. 2.0\u2009mm, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) with protruded morphology (protruded\/superficial, elevated: 14\/3 vs. 8\/42, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), most prominently in the gastric angulus. The variability in nodule size was significantly higher in the NHPHi\u2010MNG group than in the HPi\u2010NG group (0.85 vs. 0.37\u2009mm, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), reflecting nodule heterogeneity. The distance from the gastric angulus to the proximal end of the nodular lesions was significantly greater in the NHPHi\u2010MNG group than in the HPi\u2010NG group (4.4 vs. 1.7\u2009cm, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The nodules in the HPi\u2010NG group were smaller, superficial, elevated, and most prominent in the gastric antrum compared with those in the NHPHi\u2010MNG group. They were predominantly distributed in the gastric antrum with a homogeneous morphology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NHPHi\u2010MNG and HPi\u2010NG can be endoscopically differentiated according to nodule morphology and distribution. Recognizing these distinguishing features is essential for an accurate diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.15042","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T03:30:09Z","timestamp":1746761409000},"page":"998-1009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endoscopic features differentiating non\u2010<i>Helicobacter pylori Helicobacter<\/i>\u2010induced gastric mucosa\u2010associated lymphoid tissue lymphoma with a nodular gastritis\u2010like appearance and <i>H. pylori<\/i>\u2010induced conventional nodular gastritis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4916-9206","authenticated-orcid":false,"given":"Yuki","family":"Kitadai","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Graduate School of Biomedical and Health Sciences, Hiroshima University  Hiroshima 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