{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:39:59Z","timestamp":1781969999154,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016213","name":"University of Toyama","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016213","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012319","name":"National Center for Global Health and Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n \n Gastric cancer (GC) may be diagnosed after\n \n Helicobacter pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication, sometimes with submucosal invasion; however, its clinical features on regular endoscopic surveillance remain unclear. This study evaluated invasive GC's characteristics after\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication during regular endoscopic surveillance by comparing them with intramucosal cancers.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective multicenter study across 14 institutions between 2001 and 2022 evaluated patients with GC with submucosal or deeper invasion after surgical or endoscopic resection (invasive GC), compared to patients with intramucosal GC from high\u2010volume facilities. GC depth was analyzed using logistic regression (patient and mucosal factors as covariates), with significant factors explored in a subanalysis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In total, 116 of 413 patients with invasive GC and 189 of 545 with intramucosal GC were eligible for analysis. Invasive GC exhibited the following characteristics: (1) GC was a more common reason for\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication (adjusted odds ratio [OR] 2.67; 95% confidence interval [CI] 1.25\u20135.69); (2) the upper third of the stomach was the more common site (OR 2.63; 95% CI 1.41\u20135.30); and (3) map\u2010like redness (MLR) could not be confirmed (OR 4.12; 95% CI 2.53\u20136.69). Subgroup analysis suggested that GC with less MLR occurred more often in younger females (\n p<\/jats:italic>\n \u2009<\u20090.004), showed antral intestinal metaplasia (\n p<\/jats:italic>\n \u2009<\u20090.001), and was common in undifferentiated or mixed\u2010type GC (\n p<\/jats:italic>\n \u2009<\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Characteristic findings of invasive GC during regular endoscopic surveillance after\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication were associated with less MLR, along with\n \n H. pylori<\/jats:italic>\n <\/jats:styled-content>\n eradication due to GC and the upper gastric lesion locations.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/den.70043","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T03:10:34Z","timestamp":1759115434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Features of Invasive Gastric Cancer Developed After\n Helicobacter pylori<\/i>\n Eradication During Regular Endoscopic Surveillance"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4219-554X","authenticated-orcid":false,"given":"Akiko","family":"Sasaki","sequence":"first","affiliation":[{"name":"Gastroenterology Medicine Center Shonan Kamakura General Hospital Kamakura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Fujisaki","sequence":"additional","affiliation":[{"name":"Foundation for Detection of Early Gastric Carcinoma Tokyo Japan"},{"name":"Division of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2766-642X","authenticated-orcid":false,"given":"Masaaki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Niigata Cancer Center Hospital Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Namikawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kumazawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Cancer Institute Hospital, Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-3599","authenticated-orcid":false,"given":"Shu","family":"Hoteya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Shibagaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine Shimane University Shimane Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshi","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Fukuoka University Chikushi Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9194-7392","authenticated-orcid":false,"given":"Mitsushige","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Division of Genome\u2010Wide Infectious Microbiology, Research Center for GLOBAL and LOCAL Infectious Diseases Oita University Oita Japan"},{"name":"Department of Gastroenterological Endoscopy Tokyo Medical University Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3557-7649","authenticated-orcid":false,"given":"Takashi","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Endoscopy Tokyo Medical University Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-6921","authenticated-orcid":false,"given":"Seiichiro","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Endoscopy National Cancer Center Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5370-1009","authenticated-orcid":false,"given":"Hiroya","family":"Ueyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Juntendo University Faculty of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-9470","authenticated-orcid":false,"given":"Masaaki","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical Sciences Oita University Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Faculty of Medicine Oita University Oita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Isomoto","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Nephrology, 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Medicine Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2629-0830","authenticated-orcid":false,"given":"Moriya","family":"Iwaizumi","sequence":"additional","affiliation":[{"name":"Department of Endoscopic and Photodynamic Medicine Hamamatsu University School of Medicine Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mototsugu","family":"Kato","sequence":"additional","affiliation":[{"name":"Hokkaido Cancer Society Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin'ichi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology National Hospital Organization, Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Yagi","sequence":"additional","affiliation":[{"name":"Niigata Association of Occupational Health Niigata 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