{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:47:27Z","timestamp":1787845647078,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of endoscopic papillectomy (EP) for ampullary neuroendocrine tumors (Amp\u2010NETs) remains uncertain due to concerns regarding lymph node (LN) metastasis and recurrence. This study evaluated the long\u2010term outcomes of EP for Amp\u2010NETs, focusing on recurrence and procedural safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with histologically confirmed Amp\u2010NETs who underwent EP at a single tertiary center between 2004 and 2018 were retrospectively reviewed. Inclusion criteria were tumor size &lt;\u20093\u2009cm and absence of radiologic evidence of LN or distant metastasis. Outcomes assessed included recurrence, procedure\u2010related adverse events, and recurrence\u2010free survival (RFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010four patients were included. En bloc resection was achieved in 33 patients (97.1%), while complete resection was achieved in 19 patients (55.9%). Over a median follow\u2010up of 68.5\u2009months, recurrence occurred in three patients (9.1%). All recurrences occurred exclusively in patients with positive resection margins (20%, 3\/15), whereas no recurrence was observed in margin\u2010negative patients (0%, 0\/19). Early adverse events occurred in 13 patients (38.2%; bleeding\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912, pancreatitis\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093), while late adverse events developed in 4 patients (11.8%; papillary stricture), all of which were managed successfully with endoscopic treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EP is a safe and effective option for small, well\u2010differentiated Amp\u2010NETs without radiologic evidence of LN metastasis. Although the incomplete resection rate is concerning, the absence of recurrence in margin\u2010negative patients supports EP as a viable treatment option in carefully selected cases. Patients with positive margins warrant close surveillance and consideration of additional surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.70064","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T16:06:10Z","timestamp":1763481970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Outcomes Following Endoscopic Papillectomy for Ampullary Neuroendocrine Tumors"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9801-3172","authenticated-orcid":false,"given":"Yoonchan","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwook","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Mo","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8664-4090","authenticated-orcid":false,"given":"Sung Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunn","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Jun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Wan","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine  Seoul South Korea"},{"name":"Division of Gastroenterology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335595"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.038"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-013-2365-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra031623"},{"key":"e_1_2_9_6_1","first-page":"572","article-title":"A Selective Approach to the Resection of Cystic Lesions of the Pancreas: Results From 539 Consecutive Patients","volume":"244","author":"Allen P. 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