{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:34:52Z","timestamp":1778682892341,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771133"],"award-info":[{"award-number":["81771133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970995"],"award-info":[{"award-number":["81970995"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371193"],"award-info":[{"award-number":["82371193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20357"],"award-info":[{"award-number":["U21A20357"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>To compare the incidence of hypoxia and other sedation\u2010related adverse events (AEs) in overweight patients undergoing gastrointestinal (GI) endoscopy who were sedated using ciprofol or propofol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized, controlled trial was conducted in five hospitals in China between September 2022 and August 2023. Patients were randomized into either ciprofol or propofol sedation. The primary outcome was the total incidence of hypoxia and severe hypoxia. The secondary outcomes were hypoxia incidence, severe hypoxia incidence, subclinical respiratory depression incidence, endoscopy success rate, injection pain incidence, and corrective hypoxic measures proportion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1018 patients were randomized into either ciprofol group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009506) or propofol group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009512). The mean BMI was 26.23\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      in the ciprofol group and 26.17\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      in the propofol group. Compared with propofol, ciprofol showed lower incidences of total hypoxia and severe hypoxia in both the full analysis set (FAS) and per\u2010protocol analysis set (PPS). The lower incidence was particularly significant for severe hypoxia (4.35% vs. 7.62%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028 in FAS). The injection pain incidence was significantly lower in the ciprofol group than in the propofol group (2.57% vs. 13.28%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 in FAS). Moreover, fewer patients in the ciprofol group required oxygen\u2010correction therapy (20.40% vs. 25.70%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047 in PPS), and ciprofol had a lower incidence of AEs associated with sedation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>During GI endoscopy, overweight patients are significantly less prone to hypoxia when sedated with ciprofol than with propofol, offering a safer alternative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      (NCT05518929)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.70102","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T12:34:57Z","timestamp":1770035697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ciprofol Versus Propofol for the Prevention of Hypoxia During Gastrointestinal Endoscopy Procedures in Overweight Patients: A Multicenter, Randomized, Controlled Trial"],"prefix":"10.1111","volume":"38","author":[{"given":"Renlong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Renji Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanbing","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Renji Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongxue","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Renji Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Zhejiang Tumor Hospital  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penglu","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Zhejiang Tumor Hospital  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linzhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Second Hospital of Shanxi Medical University  Taiyuan 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Anesthesiology Dalian Municipal Friendship Hospital  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Renji Hospital, School of Medicine Shanghai Jiaotong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-1025","authenticated-orcid":false,"given":"Diansan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital Zhejiang University School of Medicine  Zhejiang 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