{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T12:24:16Z","timestamp":1792239856371,"version":"4.4.0"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Computer\u2010aided detection (CADe) is anticipated to enhance adenoma detection rate (ADRs). The aim of this study was to systematically collect randomized\u2010controlled trials comparing colonoscopy with CADe to standard colonoscopy without CADe in ADRs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a Bayesian network meta\u2010analysis of randomized\u2010controlled trials. Three electronic databases including MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched. The primary outcome was the comparison of the performance of CADe systems in ADRs; the secondary outcome was the sessile serrated lesions detection rates (SSLDRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 48 randomized controlled trials involving 38,986 patients were included in the quantitative analysis. Several CADe systems improved ADR compared with controls that ENDO\u2010AID (risk ratio [RR] 1.26, 95% credible interval [CrI] 1.14\u20131.40), CADEYE (RR 1.18, 95% CrI 1.10\u20131.26), and GI Genius (RR 1.15, 95% CrI 1.08\u20131.22) were supported by moderate confidence evidence according to the Confidence in Network Meta\u2010Analysis (CINeMA). For SSLDR, ENDO\u2010AID (RR 1.36, 95% CrI 1.03\u20131.79) and GI Genius (RR 1.25, 95% CrI 1.08\u20131.46) may offer improved detection compared with controls. Across multiple sensitivity analyses excluding studies by withdrawal time, conflicts of interest, limited study numbers, image\u2010enhanced endoscopy, non\u2010parallel design, single\u2010center settings, operator experience, or earlier publication years, the direction and magnitude of ADR improvements with CADe systems remained largely consistent with the primary analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on the CINeMA framework, the certainty of evidence ranged from low to moderate, indicating that some CADe systems are likely to improve ADR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.70138","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T06:38:37Z","timestamp":1774852717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparative Performance of Artificial Intelligence\u2010Based Computer\u2010Aided Detection Systems for Colorectal Polyps: A Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1111","volume":"38","author":[{"given":"Satoshi","family":"Shinozaki","sequence":"first","affiliation":[{"name":"Shinozaki Medical Clinic  Utsunomiya Tochigi Japan"},{"name":"Division of Gastroenterology, Department of Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4477-4238","authenticated-orcid":false,"given":"Jun","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterological, General and Transplant Surgery, Department of Surgery Jichi Medical University  Shimotsuke Tochigi Japan"},{"name":"Division of Community and Family Medicine Jichi Medical University  Shimotsuke Tochigi Japan"},{"name":"Division of Gastroenterology and Farncombe Family Digestive Health Research Institute, Department of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kanno","sequence":"additional","affiliation":[{"name":"R &amp; D Division of Career Education for Medical Professionals, Medical Education Center Jichi Medical University  Shimotsuke Tochigi Japan"},{"name":"Division of Gastroenterology Tohoku University Graduate School of Medicine  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9493-3957","authenticated-orcid":false,"given":"Katsuyuki","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Japan Community Health Care Organization Utsunomiya Hospital  Utsunomiya Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0160-432X","authenticated-orcid":false,"given":"Tomonori","family":"Yano","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1309086"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907667"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.429"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2022.03.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.07.021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.01.260"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/M22-3678"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-7500(22)00042-5"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/ANNALS-24-00981"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2024.08.033"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28030149"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.04.042"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.05.025"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.03.016"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1373"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099682"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003082"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14020581"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2022.09.023"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002664"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-024-11466-7"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.23922\/jarc.2024-057"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12354"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2239-8145"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528085"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1849-6878"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2210-7999"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.14573"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003500"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1966-0661"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2023.2212309"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00104-8"},{"key":"e_1_2_10_37_1","article-title":"Improvement in Adenoma Detection Rate by Artificial Intelligence\u2010Assisted Colonoscopy: Multicenter Quasi\u2010Randomized Controlled Trial","volume":"13","author":"Lagstr\u00f6m R. 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