{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T05:42:06Z","timestamp":1785303726655,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Computer\u2010aided detection systems (CAD EYE EW10\u2010EG01; Fujifilm, Tokyo, Japan) approved for clinical use in Japan have been developed to support endoscopists in the detection of gastric neoplasms during esophagogastroduodenoscopy (EGD). This prospective study aimed to evaluate the clinical performance of CAD EYE for gastric neoplasms by using white\u2010light imaging (WLI) and linked color imaging (LCI) under real\u2010world clinical conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, non\u2010randomized, confirmatory trial enrolled patients with histologically confirmed gastric neoplasms at four Japanese institutions. Each lesion was sequentially observed during EGD using WLI\u2010CAD EYE and LCI\u2010CAD EYE. The primary endpoint was the sensitivity of the CAD EYE response for known gastric neoplasms, and the secondary endpoints included the characteristics of lesions without CAD EYE response and newly identified lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 174 lesions were analyzed using the WLI\u2010CAD EYE and 173 using the LCI\u2010CAD EYE. The overall sensitivities were 92.0% (95% confidence interval [CI], 86.9%\u201395.5%) and 96.5% (95% CI, 92.6%\u201398.7%), respectively. The lower bound of the 95% CI for LCI\u2010CAD EYE exceeded the prespecified threshold of 90%, fulfilling the confirmatory criteria. WLI\u2010CAD EYE and LCI\u2010CAD EYE responses were observed in 57.4% and 59.2% of known lesions in a distant view, respectively. WLI\u2010CAD EYE showed relatively low sensitivity for lesions &lt;\u200910\u2009mm (88.9%) and those located on the anterior wall (79.4%), whereas LCI\u2010CAD EYE achieved \u2265\u200990% sensitivity in all subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LCI\u2010CAD EYE demonstrated a high sensitivity for known gastric epithelial neoplasms in a clinical setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.70172","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:10:50Z","timestamp":1778904650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Performance of Computer\u2010Aided Detection System for Gastric Neoplasms: A Non\u2010Randomized Confirmatory Trial (G\u2010\n                    <scp>CADe<\/scp>\n                    Trial) (With Video)"],"prefix":"10.1111","volume":"38","author":[{"given":"Osamu","family":"Dohi","sequence":"first","affiliation":[{"name":"Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Jichi Medical University  Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyasu","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Endoscopy Division Chiba Cancer Center  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Hirai","sequence":"additional","affiliation":[{"name":"Endoscopy Division, National Cancer Center Hospital  Tokyo 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