{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:55Z","timestamp":1787014075952,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tumors of the parapharyngeal space (PPS) are difficult to biopsy because of their deep location and proximity to major neurovascular structures. Existing percutaneous, transoral, and transnasal approaches have limitations and variable success. This study evaluated a novel transoral biopsy technique for PPS tumors using a flexible echoendoscope for endoscopic ultrasound\u2010guided fine\u2010needle biopsy (EUS\u2010FNB). We retrospectively reviewed adults with PPS tumors who underwent transoral EUS\u2010FNB at a tertiary cancer hospital from January 2020 to April 2025. Under deep intravenous sedation, the echoendoscope was advanced transorally into the oropharynx and torqued toward the tumor side. The EUS transducer was positioned against the lateral pharyngeal wall to visualize the lesion. EUS\u2010FNB was performed using end\u2010cutting needles, suction, and fanning or torquing technique. Samples were assessed macroscopically for tissue cores and processed for histopathology. Data on tumor characteristics, technical success, diagnostic yield, and adverse events were collected. Twenty\u2010one patients were included (median tumor diameter 30\u2009mm; interquartile range, 18\u201337). Tumors were successfully visualized and biopsied in 18 of 21 patients, and all samples were diagnostic. Visualization failed in three patients; the technical success and diagnostic yield were both 86% (95% CI, 65\u201396). Adverse events occurred in 6 of 18 patients (33%; 95% CI, 16\u201356) and were mostly mild: five AGREE grade I events (self\u2010limiting sore throat) and one grade II event (parapharyngeal inflammation treated with antibiotics). Transoral EUS\u2010FNB appears to be a feasible and minimally invasive technique for diagnosing PPS tumors with a high diagnostic yield and an acceptable safety profile in selected patients.<\/jats:p>","DOI":"10.1111\/den.70189","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T06:00:57Z","timestamp":1779948057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transoral Endoscopic Ultrasound\u2010Guided Fine\u2010Needle Biopsy of Parapharyngeal Space Tumors: Evaluation of Feasibility, Diagnostic Yield, and Safety (With Video)"],"prefix":"10.1111","volume":"38","author":[{"given":"Marcin","family":"Polkowski","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Clinical Oncology Center of Postgraduate Medical Education  Warsaw Poland"},{"name":"Department of Oncological Gastroenterology The Maria Sk\u0142odowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Mr\u00f3z","sequence":"additional","affiliation":[{"name":"Department of Pathology The Maria Sk\u0142odowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"},{"name":"Department of Pathomorphology Center of Postgraduate Medical Education  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Lenarcik","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Clinical Oncology Center of Postgraduate Medical Education  Warsaw Poland"},{"name":"Department of Pathology The Maria Sk\u0142odowska\u2010Curie National Research Institute of Oncology  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Pa\u0142ucki","sequence":"additional","affiliation":[{"name":"Department of Radiology The Maria Sk\u0142odowska\u2010Curie 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